Genetics Of Stroke

今年，我们扩展了中风的全基因组关联分析。 这项工作的初始阶段于2007年发表，来自这项工作的基因型保存在NIH中央全基因组关联数据库dbGAP中。我们现在已经将这项工作扩展到包括超过1500个缺血性卒中样本和1000个对照的全基因组基因分型，每个个体的基因型密度约为555，000。神经遗传学实验室正在进行简单疾病关联的分析，我们预计明年将完成这项全基因组关联研究。与我们在马约诊所的同事一起，我们也使用该项目中产生的全基因组SNP数据来执行来自脑成像数据的结果的全基因组关联。我们目前正在对较大病例对照组的全基因组关联分析的Ia期阳性相关基因座进行随访重测序。

In this year, we have extended our whole genome association analysis of stroke. The initial phase of this work was published in 2007 and the genotypes from this effort deposited in the NIH central genome wide association database dbGAP. We have now expanded this work to include genome wide genotyping of greater than 1500 ischemic stroke samples and 1000 controls at a density of approximately 555,000 genotypes per individual. The analysis of the simple disease association is ongoing within the Laboratory of Neurogenetics and we envisage that during the next year we will complete this genome wide association study. With our colleagues at the Mayo clinic we are also using the genome wide SNP data generated in this project to perform genome wide association of results from brain imaging data. We are currently involved in follow up resequencing of positively associated loci from stage Ia of the genome wide association analysis in larger case control cohorts.