Optimization of tissue depletion for LCM-MS coupling

为了实现这一目标，必须购买最先进的质量 光谱测量仪器拟议工作的理由是，一旦最佳 使用先进的质谱和相关的癌蛋白质组学方法建立方法参数， 促进方法开发的技术，研究感兴趣的实体瘤， 同质组织学肿瘤/组织细胞（即，肿瘤本身、间质等）可以 有效地研究生物标志物，药物靶点和途径，目的是改善我们的 对特定疾病状态的基本了解。

To accomplish this goal, it was essential to purchase state of the art mass spectrometry instrumentation. The rationale for the proposed work is that, once the optimal method parameters are established using advanced mass spectrometry and relevant oncoproteomic technologies to facilitate method development, to investigate a solid tumor of interest, homogeneous histological tumor/tissue cells (i.e., tumor proper, stroma, etc) can be effectively studied for biomarkers, drug targets, and pathways, with the goal of improving our basic understanding of a given disease-state.