BRAIN AGING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目是对人类、黑猩猩和其他非人类灵长类动物的正常和病理性脑老化的比较研究，具体目标是了解为什么人类是唯一患阿尔茨海默病的灵长类动物。 我们正在使用比较神经影像学来确定不同年龄组的脑灰质体积、白色物质体积和白色物质完整性的物种差异和相似性。 此外，我们正在比较死后组织中显微脑解剖学和分子生物学的年龄相关变化。 这包括记录人类和非人灵长类动物中β-淀粉样蛋白寡聚体的种类，包括人类特有的形式，并鉴定结合人类特异性形式的配体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is a comparative study of normal and pathological brain aging in humans, chimpanzees, and other nonhuman primates, with the specific goal of understanding why humans are the only primates that develop Alzheimer's disease. We are using comparative neuroimaging to identify species differences and similarities in brain gray matter volume, white matter volume, and white matter integrity across age groups. In addition, we are comparing age-related changes in microscopic brain anatomy and molecular biology in postmorten tissue. This includes documenting the varieties of beta-amyloid oligomes in humans and nonhuman primates, including forms specific to humans, and identifying ligands that bind human-specific forms.