RESTING STATE FUNCTIONAL CONNECTIVITY IN CHIMPANZEES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 功能磁共振成像已经被用来检测静息的人脑中的功能连接网络。由于这些网络既存在于静止状态，也存在于轻度麻醉状态，因此有可能在轻度麻醉的黑猩猩身上识别它们，并将它们与在人类中发现的网络进行比较，以了解人类和黑猩猩的大脑相似的组织程度。 这可能有助于我们确定支持人类认知和行为特化的人脑连接的特化，也将有助于揭示人类大脑的进化。在报告期间，我们制定了纠正T2*加权扫描中的扭曲的技术，以便将它们准确地注册到解剖T1扫描中。此外，我们开始了对黑猩猩大脑皮质连接的研究，方法是在选定的皮质区域播种，并确定显示相关活动的区域。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. fMRI has been used to detect functionally connected networks in the resting human brain. Because these networks are present both at rest and also in the lightly anesthetized state, it is possible to identify them in lightly anesthetized chimpanzees and compare them with those found in humans to inform our knowledge of the extent to which human and chimpanzee brains are similarly organized. This may help us to identify specializations of human brain connectivity that support human cognitive and behavioral specializations and will also shed light on human brain evolution. During the reporting period, we worked out techniques for correct distortions in the T2*-weighted scans so as to register them accurately to the anatomical T1 scans. In addition, we began studies of connectivity in chimpanzees by seeding selected regions of cortex and identifying territories that show correlated activity.