Training Program in Hematology

描述（由申请人提供）：血液学学科一直是将免疫学、分子生物学和细胞生物学的基础科学发现转化为人类有希望的新疗法的典范。为了最大限度地将新生的科学知识转化为临床血液学，我们需要保持有天赋和训练有素的医生科学家的队伍，他们将在实验室和临床之间进行转化。为了将基础科学与临床研究完全联系起来，实习生必须在一个激励和培育的研究环境中接受严格的实验室培训和强有力的指导。不幸的是，在血液学方面缺乏受过这样训练的年轻研究人员。最近一项针对美国和加拿大成人和儿童血液学/肿瘤学亚专科培训项目主任的调查发现，血液学学术培训的研究员缺乏(1)。该研究指出，“少数学员选择血液学单一资格（100/ 0）并追求非恶性血液学职业（成人培训项目毕业生中<6%），这引起了人们的关注。”约翰霍普金斯大学的血液学部门是该国为数不多的独立血液学项目之一。因此，建议的培训计划的目的是为血液学领域的研究事业准备具有医学博士和/或博士学位的合格个人。该血液学研究培训项目为准备从事血液学研究全职工作的个人提供跨学科的实验室培训。受训者在主要研究人员的实验室中从事与良性和恶性血液疾病生物学相关的项目。这些研究项目，加上参加课程作业、研究研讨会、期刊俱乐部、实验室会议和参加国家和国际会议，使受训者获得基本知识和必要的技能，使他们能够成功地作为独立研究者发挥作用。

DESCRIPTION (provided by applicant): The discipline of Hematology continues to be a model for translating basic scientific discoveries in immunology, molecular biology, and cellular biology into promising new therapies for human beings. To maximize our opportunity to translate nascent scientific knowledge into clinical hematology, we need to perpetuate the pool of gifted and highly trained physician-scientists who will translate between the laboratory and the clinic. To fully link basic science with clinical investigation, a trainee must receive rigorous laboratory training and strong mentoring in a stimulating and nurturing research environment. Unfortunately, there is a shortage of young investigators with such training in the discipline of hematology. A recent survey of directors of adult and pediatric hematology/oncology subspecialty training programs in the United States and Canada found a deficiency in fellows trained in academic Hematology (1). The study stated that, "Concern is raised over the small numbers of trainees who opt for single-board eligibility in Hematology (100/o) and pursue careers in nonmalignant Hematology (<6% of graduates of adult training programs)." The Division of Hematology at Johns Hopkins is one of the few remaining free-standing Hematology Programs in the country. Thus, the purpose ofthe proposed training program is to prepare qualified individuals with an M.D. and/or Ph.D. degree for a research career in the field of Hematology. This program for research training in hematology provides interdisciplinary laboratory training for individuals preparing for full-time careers in hematology research. Trainees work on projects relevant to the biology of benign and malignant blood disorders in the laboratories of leading investigators. These research projects, in conjunction with participation in course-work, research seminars, journal clubs, laboratory meetings, and attendance at National and International meetings, afford trainees the basic knowledge and required skills to function successfully as independent investigators.