Genomics

成功地解开了人类基因组的性质和功能动力学，以及重要的 计算生物学的进步，基因组相关现象的科学研究加速了我们的 了解癌症和其他人类疾病的发病机制。重点放在基础分子 致病机制，如染色体异常、遗传易感性和基因组结构 作为基因功能的表观遗传、转录和转录后调节。为了实现这一目标 以基因组为导向的研究目标并使相关方法易于为纽约大学个人所用 癌症研究所的研究人员在开始他们的研究生涯时，发展机构势在必行 将支持这一努力的核心设施。纽约大学癌症研究所(NYU CL)在Dr。 史蒂文·布拉科夫为应对现代功能基因组的挑战做出了重大努力。 通过建立最先进的基因组学设施和最近的RNAi核心设施来促进科学发展。这些 两个核心实验室密切合作，为纽约大学CL调查人员提供服务和专业知识 在微阵列或基于实时定量聚合酶链式反应的基因和微RNA表达谱中，蛋白质- DNA在染色质结构研究中的相互作用，在DMA分析中，例如用于基因分型的SNP分析，复制 多项研究，SNP、突变或CpG岛甲基化研究的DNA测序，最后是 高通量RNA干扰筛选。

Successful unraveling of the nature and functional dynamics of the human genome together with significant advances in computational biology, scientific research of genome-related phenomena have accelerated our understanding of pathogenesis of cancer.and other human diseases. The focus is at fundamental molecular pathomechanisms such as chromosomal abnormalities, genetic susceptibility, and genome structure as well as the epigenetic, transcriptional and post-transcriptional regulation of gene function. In order to realize the goals of genome-oriented research and to make relevant methodologies readily available to individual NYU Cancer Institute researchers as they embark on their research career, it is imperative to develop institutional core facilities that will support such an effort. The NYU Cancer Institute (NYU Cl) under the leadership of Dr. Steven Burakoff has made a significant effort to respond to the challenges of modern functional genomic science by establishing a state-of-the-art Genomics Facility and most recently the RNAi Core Facility. These two core laboratories work in close co-operation to provide NYU Cl investigators with services and expertise in microarray- or quantitative real-time PCR-based profiling of gene and microRNA expression, of protein- DNA interactions in chromatin structure studies, in DMA analysis such as SNP analysis for genotyping, copy number studies, and DNA sequencing for SNP, mutation or CpG-island methylation studies, and finally with high-throughput RNA interference screens.