Pathology Resource Network

病理学资源网络(以前的翻译研究组织支持资源) 整合了三个功能，组织采购，石蜡档案和白血病组织库 监督卡尔莫里森，医学博士，DVM，分子病理科主任， 病理学与检验医学。莫里森博士于1月从俄亥俄州立大学招聘 2007年。他一直负责重组资源，以满足研究所和CCSG的要求。 这一资源为基础研究和翻译研究提供了人类标本，以加深对 人类癌症的细胞和分子发病机制。总体目标是促进对人类访问 为IRB批准的研究人员提供的组织，重点是翻译工作。 组织采购的传统作用是向以下人员提供匿名新鲜和冷冻组织 调查人员需要未固定的人体组织。主要有两个变化：(1)组织采购 进行必要的更改以将大多数请求转换为大分子传输(DMA、RNA、 蛋白质)，允许其他CCSG资源更有效地使用这些珍贵材料，例如 微阵列和基因组学，并允许多个研究人员使用单一样本；(2)采购 正在建立一种机制，以允许特别收集组织，重点是翻译 研究。石蜡档案是一个器官特异性肿瘤和非肿瘤甲醛固定的储存库， 石蜡包埋的临床标本。主要有两个变化：(1)聘请专职人员 在莫里森博士的监督下的人员；(2)将这些标本组织成 利用组织微阵列的翻译主题。病理学核心设施作为研究 标本处理实验室，为个人研究人员和组织履行职能 采购和石蜡档案，从基本组织学和免疫组织化学到加工 用于组织获取和构建石蜡组织微阵列的大分子样品 存档。白血病组织库处理和冷冻保存急性白血病患者的细胞样本 分析各种血液病的分子发病机制和预后特征。 这一高度整合的资源具有良好的可控性和特色化的标本，将继续 作为加强翻译研究和协作努力的重要资源 增加同行评议的资金和出版物。 所有六个计划都使用该资源，96%的用户是CCSG成员。221,883美元 请求提供CCSG支持，占总业务预算的19%。

The Pathology Resource Network (previously Translational Research Tissue Support Resource) incorporates three functions, Tissue Procurement, Paraffin Archive and Leukemia Tissue Bank under the supervision of Carl Morrison, MD, DVM, Director of the Division of Molecular Pathology, Department of Pathology & Laboratory Medicine. Dr Morrison was recruited from The Ohio State University in January 2007. He has been responsible for reorganizing the Resource to meet Institute and CCSG requirements. This resource provides human specimens for basic and translational research to further the understanding of the cellular and molecular pathogenesis of human cancers. The overall goal is to facilitate access to human tissue for IRB-approved investigators with an emphasis on translational efforts. Tissue Procurement serves the traditional role of providing anonymous fresh and frozen tissue to investigators requiring unfixed human tissue. There are two major changes: (1) Tissue Procurement is making the necessary changes to transform a majority of requests to a macromolecule delivery (DMA, RNA, protein), allowing for a more efficient use of these precious materials by other CCSG Resources such as Microarray and Genomics and allowing multiple investigators to utilize a single specimen; (2) a procurement mechanism is being established to allow for special collections of tissues with an emphasis on translational research. The Paraffin Archive is a repository of organ-specific neoplastic and non-neoplastic formalinfixed, paraffin-embedded clinical specimens. There are two major changes: (1) the hiring of dedicated personnel under the supervision of Dr Morrison; (2) an intense effort to organize these specimens into a translational theme utilizing tissue microarrays. The Pathology Core Facility serves as a research specimen processing laboratory and performs functions for individual investigators and for Tissue Procurement and Paraffin Archive ranging from basic histology and immunohistochemistry to processing specimens for macromolecules for Tissue Procurement and building tissue microarrays for the Paraffin Archive. The Leukemia Tissue Bank processes and cryopreserves cell samples from patients with hematological disorders for analysis of a variety of molecular pathogenetic and prognostic characteristics. This highly-integrated Resource with well controlled and characterized specimens will continue to serve as an important resource for enhancing translational research and collaborative efforts that will result in increased peer-reviewed funding and publication. The Resource is used by all six Programs and 96% of users are CCSG members. $221,883 in CCSG support is requested, representing 19% of the total operating budget.