ZINC AND COPPER EXCRETION AND ABSORPTION IN INFANTS WITH OSTOMIES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 摘要 我们建议检查锌和铜的吸收和排泄的婴儿与造口术。这将通过测量锌、铜和血浆铜蓝蛋白的基线排泄和血清水平，以及通过利用锌和铜的稳定同位素测量吸收和排泄来实现。当造口术婴儿主要接受全肠外营养（TPN），很少或没有肠内喂养时，我们将收集24小时造口术排出物以测量锌和铜排泄，并测量血清锌、铜和铜蓝蛋白水平。我们将在两个时间点使用锌和铜的稳定同位素：当婴儿仍有造口并主要接受肠内营养而不接受TPN时，以及最后，当/如果患者的造口被移除，肠道重新吻合，并且患者在肠内喂养方面稳定时。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT We propose to examine the absorption and excretion of zinc and copper in infants with ostomies. This will be accomplished by measuring baseline excretion and serum levels of zinc, copper, and ceruloplasmin, and by utilizing stable isotopes of zinc and copper to measure absorption and excretion. When an infant with an ostomy is receiving primarily total parenteral nutrition (TPN) with minimal or no enteral feeds, we will collect ostomy output for 24 hours to measure zinc and copper excretion, and will measure serum zinc, copper, and ceruloplasmin levels. We will utilize stable isotopes of zinc and copper at two time points: when the infant still has the ostomy and is receiving primarily enteral nutrition without TPN, and lastly, when/if the patients ostomy is removed with the bowels reanastamosed and the patient is stable on enteral feeds.