SPECTROSCOPIC STUDIES OF NITRIC OXIDE SYNTHASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 NOS家族是目前缺乏有效治疗的广泛疾病的新药开发的关键目标，包括中风，败血性休克，高血压和癌症。然而，由于对NOS调节的分子机制的不完全理解，NOS抑制剂尚未用于临床治疗。拟议的研究将显着提高NOS调控的基本理解，并有可能促进生物合理的开发新的选择性机制为基础的药物实体，以靶向这些临床上重要的NOS亚型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The NOS family is a key target for development of new pharmaceuticals for a wide range of diseases that currently lack effective treatments including stroke, septic shock, hypertension and cancer. However, due to an incomplete understanding of the molecular mechanisms of NOS regulation, NOS inhibitors have not yet been available for clinical treatments. The proposed studies will significantly improve the fundamental understanding of NOS regulation, and has the potential of facilitating bio-rational development of new selective mechanism-based drug entities to target these clinically important NOS isoforms.