BioAnalytical Chemistry Core

生物分析化学核心-项目总结 在快速变化的环境健康科学领域，研究需求是多样化和复杂的， 需要集成复杂的生物分析，包括识别和定量痕量金属的能力 物种形成和异生物质与生物分子靶的相互作用。执行这些分析需要高度 拥有专业知识和先进高端设备的训练有素的人员， 通常在大多数单独的研究实验室中可用。生物分析化学核心（BACC） 为NM-INSPIRES中心的研究人员提供了必要的专业知识和工具，用于各种现代化的 生物分析此外，核心提供内部分析，支持创新的协议开发， 为学生、研究员和教职员工提供与高级 设施中的分析仪器。核心还利用了对其他几个 现有的校园核心设施，使创新的生物分子方法，并提供这些服务，在 补贴价格。比获得技术更重要的是，BACC提供量身定制的专业知识 研究人员协助设计分子分析和数据解释，以优化利用 珍贵的生物样本和资源该设施将由我们的核心领导人管理， 在生物分析和研究设施方面具有强大互补专业知识的知识渊博的科学家 局核心设备主要安置在靠近大多数用户的专用空间内。 这种资源和知识的集中化提供了整合和具有成本效益的生物分析服务 向中心成员和用户提供专业知识和技术。核心分为四个单元：金属 分析化学、氧化应激、环境质谱和高级基因组学。这些 互补成分一起将为中心研究者提供连续的生物分析 全面表征对环境暴露和污染物的反应的能力。 本核心的具体目标是：1）在设计、执行和解释方面提供咨询， 需要使用先进分析仪器进行环境研究的研究; 2）开发 并验证用于检测和定量复杂环境中环境物种的新分析方法 样品;和3）提供环境研究分析方法方面的教育和培训， 个人外联、课程和讲习班，使尖端分析技术得以整合 NM-INSPIRES成员的研究。总的来说，生物分析化学核心将增加相当多的 价值的环境健康研究在新墨西哥州大学利用现有的机构和 NIH投资于研究基础设施，以实现我们NM-INSPIRES研究团队的目标。

BIOANALYTICAL CHEMISTRY CORE – PROJECT SUMMARY In the rapidly changing field of environmental health science, research needs are diverse and complex, requiring integration of sophisticated bioanalyses including the ability to identify and quantitate trace metal speciation and xenobiotic interactions with biomolecular targets. Performing these analyses requires highly trained personnel with specialized expertise and access to advanced high-end equipment, beyond what is typically available in most individual research laboratories. The BioAnalytical Chemistry Core (BACC) provides the NM-INSPIRES Center investigators with the necessary expertise and tools for a variety of modern bioanalyses. Moreover, the Core provides in-house analyses, supports innovative protocol development, and provides training to students, fellows, and faculty in the integrated applications associated with the advanced analytical instrumentation present in the facility. The Core additionally leverages access to several other existing on-campus core facilities to enable innovative biomolecular methods and provides these services at subsidized pricing. Even more important than access to the technology, the BACC provides tailored expertise to investigators to assist in the design of molecular analyses and data interpretation to optimize the utilization of valuable biological samples and resources. The facility will be managed by our Core leaders and knowledgeable staff scientists with strong complementary expertise in bioanalysis and research facility administration. The Core equipment is primarily housed in dedicated space in close proximity to most users. This centralization of resources and knowledge provides consolidated and cost-effective bioanalytical services and technical expertise to the Center members and users. The Core is organized into four units: Metals Analytical Chemistry, Oxidative Stress, Environmental Mass Spectrometry, and Advanced Genomics. These complementary components together will provide Center investigators with a continuum of bioanalytical capabilities for comprehensively characterizing the response to environmental exposures and contaminants. The Specific Aims of this Core are 1) to provide consultation in the design, execution and interpretation of studies that require the use of advanced analytical instrumentation for environmental research; 2) to develop and validate novel analytical methods for detection and quantitation of environmental species in complex samples; and 3) to provide education and training in analytical methods for environmental research through personal outreach, courses and workshops, enabling the integration of cutting-edge analytical technologies into the research of NM-INSPIRES members. Overall, the BioAnalytical Chemistry Core will add considerable value to environmental health research at the University of New Mexico by leveraging existing institutional and NIH investments in research infrastructure to achieve the goals of our NM-INSPIRES research team.