Integrative Molecular Analysis Core

综合分子分析核心

• 批准号: 10408029
• 负责人: Changjian Feng
• 金额: $ 56.06万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408029
• 关键词: Analytical Chemistry; Area; Biochemistry; Biological; Biology; Biomedical Research; Cancer Biology; Cells; Centers of Research Excellence; Collaborations; Communities; Complex; Computers and Advanced Instrumentation; Consultations; Core Facility; Data Analyses; Development; Disease; Educational workshop; Ensure; Environmental Health; Equipment; Faculty; Fostering; Funding; Goals; Growth; Health Sciences; Human Resources; Individual; Inductively Coupled Plasma Mass Spectrometry; Institutes; Interdisciplinary Study; Investigation; Knowledge; Laboratory Research; Leadership; Mass Spectrum Analysis; Mediating; Medicine; Mentors; Metals; Methodology; Methods; Modernization; Molecular; Molecular Analysis; New Mexico; Nutrient; Outcome; Oxidative Stress; Persons; Price; Productivity; Reproducibility; Research; Research Personnel; Research Support; Research Training; Resources; Sampling; Schedule; Science; Scientist; Services; Specialist; Spin Trapping; Strategic vision; Structure; Students; Technical Expertise; Technology; Trace metal; Training; United States National Institutes of Health; Universities; Work; advanced analytics; base; biological systems; cohort; cost effective; design; improved; in vivo; innovation; instrumentation; knowledge base; member; multidisciplinary; novel; novel therapeutics; outreach; programs; protocol development; public health relevance; research facility; synergism; tool; training opportunity; web page

INTEGRATIVE MOLECULAR ANALYSIS CORE – PROJECT SUMMARY In the rapidly changing field of Metals in Biology and Medicine, research needs are diverse and complex. Currently, advances in inorganic biochemistry – and its application to biomedical phenomena – require sophisticated integration of molecular analyses, including the ability to identify and quantitate trace metal speciation and metal interactions with biomolecular targets. These analyses require highly trained personnel with specialized expertise and access to advanced high-end equipment, beyond what is typically available in most individual research laboratories. The Integrative Molecular Analysis Core (IMAC) provides the UNM Center for Metals in Biology and Medicine investigators with the necessary expertise and tools for a variety of modern molecular analyses, including ICP-MS, EPR spin-trapping, and quantitative mass spectrometry. Moreover, the Core provides in-house analyses, supports innovative protocol development, and provides training to students, fellows, and faculty in the integrated applications associated with the advanced analytical instrumentation present in the IMAC facility. The Core additionally leverages access to several other existing on-campus core facilities to enable innovative biomolecular methods, and provides these services at subsidized pricing. Even more important than access to the technology, the IMAC provides tailored expertise to investigators to assist in the design of molecular analyses and data interpretation, to optimize use of valuable biological samples and resources. The facility will be managed by a cadre of specialists with strong complementary expertise in molecular analysis, research facility administration, training, and mentoring of junior faculty. The Core equipment is primarily housed in dedicated space in close proximity to most users. This centralization of resources and knowledge provides consolidated and cost-effective analytical services and technical expertise to the Center members and users. The Core is organized in three units: Metals Analytical Chemistry, Oxidative Stress, and Biological Mass Spectrometry. The Specific Aims of this Core are: 1) to create a centralized, state-of-the-art resource that provides expertise, training and instrumentation for integrative molecular analysis, focused on metal interactions with biological systems; 2) to support the research objectives of mentored PIs and cultivate a new cohort of COBRE investigators within the Center for Metals in Biology and Medicine; and 3) develop a user base of established, funded investigators for continued growth and sustainability of the core facility. The expected outcomes include enhanced multidisciplinary research capabilities that support metals programs of mentored PIs in their trajectory toward R01 level funding, and increased collaborations within UNM, and across New Mexico and other IDeA states. These outcomes will positively impact the level of research excellence at UNM and enhance investigations into novel therapeutics for metal-mediated diseases that afflict millions of people in New Mexico and worldwide.

综合分子分析核心-项目总结 在快速变化的生物和医学金属领域，研究需求是多样和复杂的。 目前，无机生物化学及其在生物医学现象中的应用的进展需要 分子分析的复杂集成，包括识别和定量痕量金属的能力 物种形成和金属与生物分子靶标的相互作用。这些分析需要训练有素的人员 拥有专业的专业知识和先进的高端设备，超越了 大多数单独的研究实验室。综合分子分析核心(IMAC)提供了UNM 金属生物和医学研究中心拥有必要的专业知识和工具，可用于各种 现代分子分析，包括电感耦合等离子体质谱、电子顺磁共振自旋捕捉和定量质谱仪。 此外，核心提供内部分析，支持创新的协议开发，并提供 对学生、研究员和教职员工进行与高级分析相关的集成应用方面的培训 IMac设备中存在的仪器。核心还利用对其他几个现有的 校园核心设施，支持创新的生物分子方法，并在 补贴定价。比获得这项技术更重要的是，iMac提供了量身定做的专业知识 协助调查人员设计分子分析和数据解释，优化利用有价值的 生物样本和资源。该设施将由一批具有强大专业知识的专家管理 在分子分析、研究设施管理、培训和指导方面的互补专业知识 初级教员。核心设备主要安装在专用空间内，离大多数用户很近。 这种资源和知识的集中提供了整合的、具有成本效益的分析服务 向中心成员和用户提供专业技术知识。核心由三个单元组成：金属 分析化学、氧化应激和生物质谱学。这一核心的具体目标是： 1)创建一个集中的、最先进的资源，为以下各项提供专业知识、培训和工具 综合分子分析，重点研究金属与生物系统的相互作用；2)支持 指导PI的研究目标并在中心内培养一批新的Cobre调查人员 生物和医学中的金属；以及3)发展现有的、资助的研究人员的用户基础，以便继续 核心设施的增长和可持续性。预期成果包括加强多学科合作 支持被指导的PI的金属计划的研究能力，正在走向R01级别的资助， 并在UNM内部以及新墨西哥州和其他理念州加强合作。这些结果将 积极影响加州大学卓越的研究水平，加强对新疗法的研究 在新墨西哥州和世界各地折磨着数百万人的金属介导性疾病。