BioAnalytical Chemistry Core

生物分析化学核心

• 批准号: 10393300
• 负责人: Changjian Feng
• 金额: $ 24.42万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-25 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10393300
• 关键词: Chemistry; Environmental Science; New Mexico; Research; Science; programs

BIOANALYTICAL CHEMISTRY CORE – PROJECT SUMMARY In the rapidly changing field of environmental health science, research needs are diverse and complex, requiring integration of sophisticated bioanalyses including the ability to identify and quantitate trace metal speciation and xenobiotic interactions with biomolecular targets. Performing these analyses requires highly trained personnel with specialized expertise and access to advanced high-end equipment, beyond what is typically available in most individual research laboratories. The BioAnalytical Chemistry Core (BACC) provides the NM-INSPIRES Center investigators with the necessary expertise and tools for a variety of modern bioanalyses. Moreover, the Core provides in-house analyses, supports innovative protocol development, and provides training to students, fellows, and faculty in the integrated applications associated with the advanced analytical instrumentation present in the facility. The Core additionally leverages access to several other existing on-campus core facilities to enable innovative biomolecular methods and provides these services at subsidized pricing. Even more important than access to the technology, the BACC provides tailored expertise to investigators to assist in the design of molecular analyses and data interpretation to optimize the utilization of valuable biological samples and resources. The facility will be managed by our Core leaders and knowledgeable staff scientists with strong complementary expertise in bioanalysis and research facility administration. The Core equipment is primarily housed in dedicated space in close proximity to most users. This centralization of resources and knowledge provides consolidated and cost-effective bioanalytical services and technical expertise to the Center members and users. The Core is organized into four units: Metals Analytical Chemistry, Oxidative Stress, Environmental Mass Spectrometry, and Advanced Genomics. These complementary components together will provide Center investigators with a continuum of bioanalytical capabilities for comprehensively characterizing the response to environmental exposures and contaminants. The Specific Aims of this Core are 1) to provide consultation in the design, execution and interpretation of studies that require the use of advanced analytical instrumentation for environmental research; 2) to develop and validate novel analytical methods for detection and quantitation of environmental species in complex samples; and 3) to provide education and training in analytical methods for environmental research through personal outreach, courses and workshops, enabling the integration of cutting-edge analytical technologies into the research of NM-INSPIRES members. Overall, the BioAnalytical Chemistry Core will add considerable value to environmental health research at the University of New Mexico by leveraging existing institutional and NIH investments in research infrastructure to achieve the goals of our NM-INSPIRES research team.

生物分析化学核心——项目摘要 在快速变化的环境健康科学领域，研究需求多样化且复杂， 需要集成复杂的生物分析，包括识别和定量痕量金属的能力 物种形成和外源生物与生物分子靶标的相互作用。执行这些分析需要高度 训练有素的人员拥有专业知识并能够使用先进的高端设备，超出了现有的水平 通常在大多数个人研究实验室中都可以使用。生物分析化学核心 (BACC) 为 NM-INSPIRES 中心研究人员提供各种现代研究所需的专业知识和工具 生物分析。此外，核心提供内部分析，支持创新协议开发，以及 为学生、研究员和教师提供与高级相关的集成应用程序的培训 设施内有分析仪器。核心还利用了对其他几个的访问 现有的校园核心设施，以实现创新的生物分子方法，并在以下地点提供这些服务： 补贴定价。比获得技术更重要的是，BACC 提供量身定制的专业知识 为研究人员提供协助设计分子分析和数据解释以优化利用 有价值的生物样本和资源。该设施将由我们的核心领导者和 知识渊博的科学家在生物分析和研究设施方面具有强大的互补专业知识 行政。核心设备主要放置在靠近大多数用户的专用空间中。 这种资源和知识的集中提供了综合且具有成本效益的生物分析服务 向中心成员和用户提供技术专业知识。核心分为四个单元： 金属 分析化学、氧化应激、环境质谱和高级基因组学。这些 互补的组件一起将为中心研究人员提供连续的生物分析 全面表征对环境暴露和污染物的响应的能力。 该核心的具体目标是 1) 提供设计、执行和解释方面的咨询 需要使用先进分析仪器进行环境研究的研究； 2）开发 并验证复杂环境物种检测和定量的新分析方法 样品； 3) 通过以下方式提供环境研究分析方法的教育和培训 个人推广、课程和研讨会，实现尖端分析技术的整合 参与 NM-INSPIRES 成员的研究。总体而言，生物分析化学核心将增加相当多的 通过利用现有的机构和资源，新墨西哥大学环境健康研究的价值 NIH 对研究基础设施的投资是为了实现我们 NM-INSPIRES 研究团队的目标。