BioAnalytical Chemistry Core

生物分析化学核心

• 批准号: 10393300
• 负责人: Changjian Feng
• 金额: $ 24.42万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-25 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10393300
• 关键词: Chemistry; Environmental Science; New Mexico; Research; Science; programs

BIOANALYTICAL CHEMISTRY CORE – PROJECT SUMMARY In the rapidly changing field of environmental health science, research needs are diverse and complex, requiring integration of sophisticated bioanalyses including the ability to identify and quantitate trace metal speciation and xenobiotic interactions with biomolecular targets. Performing these analyses requires highly trained personnel with specialized expertise and access to advanced high-end equipment, beyond what is typically available in most individual research laboratories. The BioAnalytical Chemistry Core (BACC) provides the NM-INSPIRES Center investigators with the necessary expertise and tools for a variety of modern bioanalyses. Moreover, the Core provides in-house analyses, supports innovative protocol development, and provides training to students, fellows, and faculty in the integrated applications associated with the advanced analytical instrumentation present in the facility. The Core additionally leverages access to several other existing on-campus core facilities to enable innovative biomolecular methods and provides these services at subsidized pricing. Even more important than access to the technology, the BACC provides tailored expertise to investigators to assist in the design of molecular analyses and data interpretation to optimize the utilization of valuable biological samples and resources. The facility will be managed by our Core leaders and knowledgeable staff scientists with strong complementary expertise in bioanalysis and research facility administration. The Core equipment is primarily housed in dedicated space in close proximity to most users. This centralization of resources and knowledge provides consolidated and cost-effective bioanalytical services and technical expertise to the Center members and users. The Core is organized into four units: Metals Analytical Chemistry, Oxidative Stress, Environmental Mass Spectrometry, and Advanced Genomics. These complementary components together will provide Center investigators with a continuum of bioanalytical capabilities for comprehensively characterizing the response to environmental exposures and contaminants. The Specific Aims of this Core are 1) to provide consultation in the design, execution and interpretation of studies that require the use of advanced analytical instrumentation for environmental research; 2) to develop and validate novel analytical methods for detection and quantitation of environmental species in complex samples; and 3) to provide education and training in analytical methods for environmental research through personal outreach, courses and workshops, enabling the integration of cutting-edge analytical technologies into the research of NM-INSPIRES members. Overall, the BioAnalytical Chemistry Core will add considerable value to environmental health research at the University of New Mexico by leveraging existing institutional and NIH investments in research infrastructure to achieve the goals of our NM-INSPIRES research team.

生物分析化学核心项目总结 在瞬息万变的环境健康科学领域，研究需求多样而复杂， 需要集成复杂的生物分析，包括识别和定量痕量金属的能力 物种形成和异种生物与生物分子靶标的相互作用。执行这些分析需要很高的 训练有素的人员，具有专业知识并能够获得先进的高端设备，超出 通常在大多数单独的研究实验室中可用。生物分析化学核心(BACC) 为NM-Inspirres中心的调查人员提供必要的专业知识和工具，用于各种现代 生物分析。此外，核心提供内部分析，支持创新的协议开发，以及 为学生、研究员和教职员工提供与高级 设施中有分析仪器。核心还利用了对其他几个 现有的校园核心设施，支持创新的生物分子方法，并在 补贴定价。比获得技术更重要的是，BACC提供量身定做的专业知识 协助研究人员设计分子分析和数据解释，以优化利用 宝贵的生物样本和资源。该设施将由我们的核心领导和 知识渊博的科学家，在生物分析和研究设施方面具有强大的互补专业知识 行政管理。核心设备主要安装在专用空间内，离大多数用户很近。 这种资源和知识的集中提供了整合的、具有成本效益的生物分析服务 向中心成员和用户提供专业技术知识。核心由四个单元组成：金属 分析化学、氧化应激、环境质谱学和高级基因组学。这些 互补成分的结合将为中心研究人员提供生物分析的连续体 全面描述对环境暴露和污染物的反应的能力。 本核心的具体目标是：1)在设计、执行和解释方面提供咨询 需要使用先进的分析仪器进行环境研究的研究；2)开发 并验证了用于检测和定量复合体中环境物种的新分析方法 3)为环境研究提供分析方法方面的教育和培训 个人外展、课程和讲习班，使尖端分析技术得以整合 NM--激励成员的研究。总的来说，生物分析化学核心将增加相当大的 对新墨西哥大学环境健康研究的价值通过利用现有的机构和 NIH在研究基础设施方面的投资，以实现我们NM-Inspirates研究团队的目标。