A STUDY OF T1? VALUES IN ARTICULAR CARTILAGE OF ASYMPTOMATIC SUBJECTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 磁共振成像(MRI)技术可用于关节的直接可视化 软骨及软骨损伤和丢失的评估。尽管核磁共振对于检测是准确的 对于软骨的形态缺陷，它对早期的大分子不敏感。 在关节镜检查中检测为软化的退化。T1？核磁共振技术已经证明 对软骨中的大分子降解敏感。T_1°，自旋晶格驰豫 旋转框架，作为软骨退变过程中生化变化的标志 骨性关节炎(OA)。在目前的研究中，我们测量了关节软骨的T1？松弛时间 作为年龄的函数，在无症状的受试者中确定任何趋势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Magnetic Resonance Imaging (MRI) techniques can be used for direct visualization of articular cartilage and assessment of cartilage injury and loss. Although MRI is accurate for the detection of morphologic defects of cartilage, it is insensitive to the earliest stages of macromolecular degradation that is detected as softening at arthroscopy. The T1¿ MRI technique has proven to be sensitive to macromolecular degradation in cartilage. T1¿, the spin lattice relaxation in the rotating frame, serves as a marker for biochemical changes in cartilage degeneration during osteoarthritis (OA). In the current study, we measure T1¿ relaxation times in articular cartilage as function of age in asymptomatic subjects to determine any trends.