EFFECTIVE DETECTION OF PCOS IN OLD WORLD MONKEYS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一个翻译性的多中心项目，旨在启动对女性一种高度流行的生殖和代谢障碍，即多囊卵巢综合征(PCOS)的病理生理起源的新研究。这种高雄激素综合征会增加女性患2型糖尿病、心血管疾病、子宫内膜癌和不孕症的终生风险。我们对多囊卵巢综合征的关注源于这种疾病高度普遍但异质性的本质，以及我们对其在女性中的病因学的不完全了解。我们现在需要在非人类灵长类动物模型中自然发生的表型，以及针对有多囊卵巢综合征风险的儿童的能力，以开发新的临床干预措施来预防或减少成人多囊卵巢综合征的表型。 在这个于2009年秋末开始的试点项目中，我们建议与多个灵长类中心和威斯康星州CTSA组成的联盟，确定非人类灵长类动物和人类方法的有效性。我们在三个灵长类中心有针对性地使用适当的非人类灵长类种群和专业知识，最大限度地减少了全国可用资源的冗余，我们在WCTSA中利用化验服务表明我们共享单一的核心资源。到目前为止，耶克斯中心已经收集了样本，并对所需的100名女性中的约20名进行了卵巢超声检查。所有样本都将被送到WNPRC的Abbott博士那里进行分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a translational multi-center project to initiate novel studies into the pathophysiological origins of a highly prevalent reproductive and metabolic disorder in women, namely polycystic ovary syndrome (PCOS). This hyperandrogenic syndrome increases a woman's lifetime risk of type 2 diabetes, cardiovascular disease, endometrial cancer and infertility. Our focus on PCOS stems from the highly pervasive, but heterogeneous nature of the disease, and our incomplete understanding of its etiology in women. We now need a naturally-occurring phenotype in a nonhuman primate model as well as an ability to target children at risk of PCOS to develop novel clinical interventions to prevent or diminish the adult PCOS phenotype. In this pilot project begun in late Fall 2009, we propose to establish the efficacy of both nonhuman primate and human approaches with a consortium of multiple Primate Centers and the Wisconsin CTSA. Our targeted use of appropriate nonhuman primate populations and expertise at three Primate Centers minimizes redundancies in resources available nationally and our utilization of Assay Services within the WCTSA demonstrates our sharing of a single core resource. Thus far, the Yerkes Center has collected samples and performed ovarian ultrasounds on some 20 of the 100 females needed. All samples will be sent to Dr Abbott at the WNPRC for analyses.