Analytical Biochemistry Shared Resource

该设施自1990年开始运营，为癌症中心（CC）研究人员提供与癌症研究相关的具有成本效益和准确的化学分析。它也是与分析化学中分析物的定量和策略有关的咨询的基础。我们提供先进方法方面的服务和专业知识，包括最先进的技术，特别是液相色谱-质谱法（LCMS）和多路免疫分析。此外，常规分析和临床标志物的测定提供给研究者。由于CC成员的需要，在当前周期中实施了一系列新的检测方法。在夏威夷州，没有其他实验室可以提供这些服务，特别是在检测的类型、速度、成本和组合方面，其中许多是由该中心定制设计的，以满足CC项目的特定要求。通过参加内部和外部质量保证方案，包括参加由国家标准与技术研究所组织的循环测试，不断监测高质量的服务。该核心的可用性提供了最先进的服务，改善了对研究人员的反馈，促进了跨学科合作，并为CC研究人员提供了具有成本效益的服务。预计在可预见的未来，目前的满负荷使用将继续下去。需要该资源服务的新资助项目将超过在未来几年终止的项目。在本周期内，通过CCSG支助赠款获得的设备大大提高了这一资源的潜力。该设施显示出显著的增长：自上一个周期以来，其生产率提高了84%，人员和收入也相应增加。在06-11财年期间，共有79份与癌症相关的同行评议出版物强调了这一核心的巨大价值，这些出版物涉及ABSR的服务（58%是方案间的，13%是方案内的）。

This facility, operating since 1990, provides cost-effective and accurate chemical analyses for molecules relevant to cancer research of Cancer Center (CC) investigators. It is also a base for consultation related to the quantitation of analytes and strategies in analytical chemistry. Services and expertise in advanced methods are available including state-of-the-art techniques, particularly liquid chromatography mass spectrometry (LCMS) and multiplexed immunoassays. In addition, routine analyses and determinations of clinical markers are offered to investigators. A host of new assays have been implemented in the current cycle due to needs of CC members. No other laboratories are available to provide many of these services in the State of Hawai'i, particularly regarding type, speed, cost, and combinations of assays, many of which are custom designed by this core to fulfill the specific requirements of CC projects. The high quality of services is continually monitored by taking part in internal and external quality assurance programs including the participation in round robin tests organized by the National Institute of Standards and Technology. The availability of this core provides state-of-the-art services, improves feedback to the investigators, stimulates inter-disciplinary collaborations, and provides cost effective service to CC investigators. The current use at full capacity is anticipated to continue for the foreseeable future. Newly funded projects requiring services of the resource will outnumber projects terminating in the coming years. Equipment obtained through the CCSG support grant in the current cycle has greatly enhanced the potential of this resource. This facility has shown remarkable growth: its productivity increased by 84% since the last cycle and has grown accordingly in personnel and revenue. The great value of this core is underscored by a total of 79 cancer related peer reviewed publications during FY06-11 that involved services by the ABSR (58% inter-programmatic, 13% intra-programmatic).