BIOSTATISTIC AND DATA MANAGEMENT CORE

项目摘要：生物统计和数据管理核心(核心E)建议是计划项目拨款(PPG)应用的一部分，目的是阐明遗传性和散发性额颞叶痴呆(FTD)或额颞叶变性(FTLD)的大脑退化机制。该核心支持所有数据管理、统计和计算需求，并为该PPG内所有核心和项目1-4的面向患者的研究数据维护PPG数据库。这个 所提供的服务包括：(A)支持数据表格/调查表的设计和开发、数据库开发和管理、数据输入、数据库审计跟踪、数据库安全、数据库备份和严格的数据质量控制程序；(B)为所有PPG活动提供计算和编程支持，包括实施和整合数据管理和研究所需的硬件和软件升级，以及计算系统的日常和存档异地备份 (C)为研究的所有方面提供生物统计学支持，包括从开始到发表的所有方面，包括制定研究设计、进行样本量和能量计算、采用随机化方案和对PPG数据进行分析；(D)根据需要开发新的统计方法，以进行数据分析。因此，核心E发挥着重要和重要的作用，这对研究的进展和在本PPG中进行的研究至关重要。本核心建议的研究，连同在其他核心和本PPG的所有4个项目中进行的补充研究，将使人们更好地理解患有tau病理的FTLD和患有TDP-43病理的FTLD的神经退行性机制，这可能会加强努力，为这些疾病开发更好的诊断和治疗干预措施。

PROJECT SUMMARY: The Biostatistics and Data Management Core (Core E) proposal here is part of a Program Project Grant (PPG) application to elucidate mechanisms of brain degeneration in hereditary and sporadic frontotemporal dementias (FTD) or frontotemporal lobar degeneration (FTLD). This core supports all data management, statistical, and computing needs, as well as maintains the PPG database for data from patient-oriented studies for all Cores and Projects 1-4 within this PPG. The provided services includes: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures; (b) computing and programming support for all PPG activities, including implementation and integration of hardware and software upgrades necessary for data management and research, as well as routine and archival off-site backup of computing systems central to the PPG, including the PPG database; (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, randomization schemes, and performing analyses of PPG data; and (d) development of new statistical methodologies where needed for data analysis. Thus, Core E plays an important and significant role that is critical to the progress of research and the conduct of studies in this PPG. The studies proposed in this Core taken together with the complementary studies conducted in the other Cores and all 4 Projects in this PPG will lead to a better understanding of the neurodegenerative mechanisms underiying FTLD with tau pathology and FTLD with TDP-43 pathology which is likely to enhance efforts to develop better diagnostics and therapeutic interventions for these disorders.