Claude D. Pepper Older Americans Independence Center (OAIC)

描述（由申请人提供）： 佛罗里达大学老年美国人独立中心（OAIC）的使命是评估老年人身体残疾的风险因素，开发和测试有效的预防和康复疗法，并培训新的调查人员研究老龄化和残疾，同时发展他们的领导素质。我们的战略是吸引来自不同行为、临床和基础科学学科的研究和调查人员，对专注于共同研究主题的老龄化研究进行研究，这反过来将使我们能够完成我们的使命。主题是“肌肉减少症、残疾的预防和康复”，将采用跨学科的方法，贯穿整个生物医学研究领域，包括分子生物学、动物研究、临床研究、行为科学和流行病学。该研究主题涉及OAIC计划的总体目标，即增加科学知识，从而更好地保持或恢复老年人的独立性。我们的研究目标是（1）评估，使用翻译研究（在基础学科和临床学科之间）多种因素，例如生物学、遗传学、共病、心理社会学和行为学，这些因素导致肌肉减少症、身体功能下降和残疾进展，以及（2）在临床和临床前研究中开发和可靠地测试靶向肌肉减少症的干预措施，以预防，延缓或恢复与年龄相关的身体功能下降和残疾进展。为了实现这些目标，拟议的OAIC将包括以下综合核心，这将支持研究者，初级学者，基础设施和服务：领导和行政核心，研究职业发展核心，试点/探索性研究核心，临床研究核心，临床前研究核心，生物统计和数据管理核心，招聘核心，基因组学和生物标志物核心。在第一年，我们将培训九名初级学者，并支持七个外部研究，三个研究开发项目，两个试点研究，一个探索性研究和九个小型试点/探索性研究。拟议的OAIC的主要优势是跨学科核心，项目和研究人员的协调行动，这些核心，项目和研究人员通过整个生物医学领域探索一个共同的研究主题。 调查

DESCRIPTION (provided by applicant): The mission of the University of Florida Older Americans Independence Center (OAIC) is to assess the risk factors of physical disability in older adults, develop and test effective prevention and rehabilitation therapies, and train new investigators in research on aging and disability, while developing their leadership qualities. Our strategy is to attract studies and investigators from diverse behavioral, clinical, and basic science disciplines towards research on aging that is focused on a common research theme, and this, in turn, will allow us to accomplish our mission. The theme, "sarcopenia, prevention and rehabilitation of disability", will be pursued using an interdisciplinary approach that traverses the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, and epidemiology. This research theme addresses the general goal of the OAIC program, namely, to increase scientific knowledge that will lead to better ways to maintain or restore independence of older persons. Our research objectives are to (1) assess, using translational research (between basic and clinical disciplines) multiple factors such as biological, genetic, co-morbid, psychosocial, and behavioral that contribute to sarcopenia, physical function decline, and progression to disability and (2) develop and reliably test in clinical and preclinical studies interventions that target sarcopenia, in order to prevent, delay or recover the age-related declines in physical function and the progression to disability. To address these objectives the proposed OAIC will include the following integrated cores, which will support investigators, Junior Scholars, infrastructure, and services: the Leadership and Administrative Core, the Research Career Development Core, the Pilot / Exploratory Studies Core, the Clinical Research Core, the Preclinical Research Core, the Biostatistics and Data Management Core, the Recruitment Core, and the Genomics and Biomarkers Core. During the first year we will train nine Junior Scholars and support seven external studies, three research development projects, two pilot studies, one exploratory study and nine small pilot/exploratory studies. A major strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects and investigators that address one common research theme to be explored through the whole spectrum of biomedical investigation.