How insulin and the insulin-like growth factors bind to their receptors - the key role of the ?-chain C-terminal helix

癌症、老年痴呆症和糖尿病是澳大利亚面临的三个最重要的健康问题。通过相关胰岛素受体和1型胰岛素样生长因子受体进入细胞内部的异常信号传导与所有这三种疾病状态有关。我们的研究旨在了解这些信号事件如何在原子水平上发生-这些知识有可能有助于开发旨在治疗这些疾病的新疗法。

Cancer, Alzheimer’s disease and diabetes are three of the most important health issues facing Australia. Aberrant signalling into the cell interior by the related insulin receptor and Type 1 insulin-like growth factor receptor is implicated in all three of these disease states. Our research is aimed at understanding how these signalling events occur at the atomic level of detail – such knowledge has the potential to contribute to the development of novel therapeutics aimed at treating these diseases.