RESOURCE CORE 3: MOBILITY FUNCTION AND NEUROMOTOR PLASTICITY

运动功能和神经运动可塑性核心(RC-3)提供专业知识和研究人员资源，以评估影响功能性运动表现的多系统神经运动、呼吸和运动行为因素。RC-3将协助和培训RCDC学者和OAIC调查人员设计新的康复干预措施，进行和解释定量运动表现 这些结果与描述大脑可塑性机制的方法相结合，以促进有功能障碍的老年人功能恢复的神经科学基础。核心支持：1)一个发展项目，该项目审查以下假设：稳定对平衡干扰的反应应 其中包括：1)意志运动主要参与涉及皮质和皮质下大脑区域的预测和运动规划过程，而对意想不到的外部事件造成的反射性平衡障碍的反应主要涉及脑干和脊髓的感觉反馈；2)PES研究中风和老年对照患者步态的皮质电生理学特征，以表征运动的动态神经运动可塑性；以及3)RCDC学者，他将在生物力学、脑电和神经成像方法方面提供指导，以研究老年人平衡和运动障碍的机制。RC-3通过研究工作组中的OAIC核心进行合作，将下一代干预措施推进到社区，这些干预措施将增强患有慢性残疾的老年人的行动功能。它对步态、平衡、姿势控制、上肢活动和功能任务(工具箱)进行质量控制测试，这些测试描述了神经运动控制和可塑性的过程，这些过程是OAIC干预下运动学习和运动衍生的功能获得的基础。在过去的5年里，RC-3为5个PES、1个DP和6个外部项目提供了核心服务，指导了2名RCDC学者和神经运动控制和神经成像方面的先进测试方法，并开发了新的干预方法。

The Mobility Function and Neuromotor Plasticity Core (RC-3) provides expertise and investigator resources to assess the multi-system neuromotor, blomeehanical, and motor behavioral factors affecting functional movement performance. RC-3 will assist and train RCDC Scholars and OAIC investigators in the design of novel rehabilitation interventions, conduct and interpretation of quantitative movement performance outcomes that are coupled to methodologies delineating the mechanisms of brain plasticity to advance the neuroscientific basis of functional recovery in older people with functional limitations. The Core supports: 1) a development project that examines the hypothesis that stabilizing responses to balance disturbances due to volitional movements primarily engage predictive and motor planning processes involving cortical and subcortical brain areas, while responses to reflexive balance disturbances due to unexpected external events primarily engage sensory feedback in the brainstem and spinal cord; 2) a PES that decodes the cortical electrophyslology of gait in stroke and older controls to characterize the dynamic neuromotor plasticity of locomotion, and another that investigates effects of split belt treadmill on locomotor re-learning after stroke; and 3) RCDC Scholar who will be mentoring in biomechanics, EEG and neuroimaging methodologies to study mechanisms of balance and mobility dysfunction in older people. RC-3 collaborates across OAIC cores in nresearch working groups to advance the next generation of interventions to the community that will enhance mobility function in older adults with chronic disability. It performs quality controlled tests of gait, balance, postural control, upper limb activities, and functional tasks (Toolbox) that characterize the processes of neuromotor control and plasticity that underlie motor learning and exercise derived functional gains across OAIC interventions. During the last 5 years, RC-3 provided core services to five PES, one DP and 6 external projects, mentored 2 RCDC Scholars and advanced testing methodology in neuromotor control and neuroimaging as well as developing new intervention methodologies.