RESOURCE CORE 1: BIOSTATISTICS, INFORMATICS AND TRANSLATIONAL RESEARCH

生物统计、信息学和翻译研究核心(RC-1)的目标是建立一个促进OAIC研究设计和执行的优秀环境，其中最佳统计实践指导数据分析，促进搜索潜在的成功干预机制，并促进将有希望的干预转化为临床和社区。核心将组织研究工作组(RWGs)，将协助设计、执行和监督马里兰大学老年美国人独立中心(OAIC)的所有研究，并将提供一个信息学骨干，GERI，将支持该中心所有方面的工作。我们将确保最佳统计做法指导OAIC研究的设计和执行、数据分析和分析结果的解释。我们将培养教职员工、RCDC学者QR。统计和流行病学原理方面的教师)和工作人员。 我们的研究工作小组由研究督导、督导(如果督导是RCDC学者)和每个核心的一名成员组成，他们将使用GERI生成的自动报告来监督OAIC研究的进展和监测研究进展。这些报告将支持研究工作小组确保及时完成开放式空气污染调查研究的努力，并将帮助研究小组确定哪些研究具有 从实验室到基于中心的研究和基于社区的干预的转化潜力。GERI将收集和跟踪对OAIC服务的请求(服务请求系统)，将协助招募受试者(注册)，将跟踪研究进展(跟踪数据库)，收集有关不良事件的信息(不良事件数据库)，并将促进实验室质量控制(质量控制和离群值检测系统)。我们的教育工作也将包括我们的系列讲座。 作为我们机构公共卫生硕士项目提供的正式教学教育，我们的K30项目提供临床研究硕士学位，以及我们在UMB的临床和翻译研究暑期课程。

The goal of the Biostatistics, Informatics, and Translational Research Core (RC-1) is to establish and an environment that promotes excellence in the design and execution of OAIC studies where best statistical practices guide the analysis of data, to facilitate the search for mechanisms underlying successful interventions, and to promote the translation of promising interventions into the clinic and community.The Core will organize Research Working Groups (RWGs) that will assist with the design, execution, and oversight of all University of Maryland Older Americans Independence Center's (OAIC) research, and will provide an informatics backbone, GERI, that will support all aspects of the Center's work. We will make sure that best statistical practices guide the design and execution of OAIC research, the analysis of data, and the interpretation of the results of the analysis. We will educate faculty, RCDC scholars Qr. faculty) and staff in the principles of statistics and epidemiology. Our Research Working Groups, composed of the study PI, the Pi's mentor (if the PI is an RCDC Scholar), and one member from each Core, will use the automated reports produced by GERI as they oversee the progress of OAIC studies and monitor study progress. The reports will support the RWGs' efforts to assure that OAIC studies are completed in a timely fashion, and will help the RWGs identify studies that have potential for translation from laboratory bench, to center-based studies, and to community-based interventions. GERI will collect and track requests for OAIC services (Request for Services System), will assist with the recruiting of subjects (Registry), will track study progress (Tracking Database), collect information regarding adverse events (Adverse Event Database), and will facilitate laboratory quality control (Quality Control and Outlier Detection Systems). Our educational efforts will include our lecture series as well as the formal didactic education provided by our institution's MPH program, our K30 program, which offers an MS in Clinical Research, and our summer course Clinical and Translational Research at UMB.