Structure Analysis of Supramolecular Assemblies by Hybrid Method

项目总结： 该项目的目标是召开一次为期四天的研讨会，主题是“用杂交方法进行超分子组装的结构分析”，汇集结构生物学不同分支的专家，主要来自X射线结晶学、电子冷冻显微镜和计算生物学领域。议程还将延伸到生物物理方法、蛋白质组学和细胞生物学。这次讲习班是在2006年3月、2004年3月和1998年4月就同一主题成功举行了三次会议之后举行的。它的目标是通过说明混合方法对具有挑战性的巨型系统的能力，以及通过识别当前实践的混合方法中的限制和差距，来调查这一令人兴奋的研究领域的最新技术。研讨会的基础是以下新兴概念：(1)大分子组件和机器代表大多数基本过程的结构层次中的关键层次；(2)通过适当的实验方法组合，即“混合方法”，可以最有效地研究这些实体。研讨会将于2008年3月12日至16日在加利福尼亚州太浩湖的Granlibakken会议上举行。它的计划将包括两次主题演讲，七次平台会议，邀请演讲(70%)和从提交的摘要中挑选演讲(30%)，以及两次海报会议。平台会议的主题如下：大分子细丝的混合方法；膜复合体的混合方法；动态组装的混合方法、杂交分析的计算方法；大分子机器的混合方法；细胞组织的混合方法和细胞蛋白质组学。D.Hanein博士和W.Sundquist博士担任会议主席，A.Steven博士、B.Geiger博士、C.M.沃特曼-斯托勒博士、R.M.斯特劳德博士和W.Baumeister博士是组委会成员。讲习班将进行广泛宣传，并将在组织者所能达到的范围内尽可能具有包容性和对多样性有敏感认识，并将允许150人参加。

Project Summary: The goal of this project is to convene a four-day Workshop on the cutting-edge topic of "Structural Analysis of Supramolecular Assemblies by Hybrid Methods," bringing together specialists in diverse branches of structural biology, drawing primarily from the fields of x-ray crystallography, electron cryomicroscopy, and computational biology. The agenda will also extend to biophysical methods, proteomics and cell biology. This Workshop follows three successful meetings on the same theme in March 2006, March 2004 and April 1998. Its goal is to survey the state of the art in this exciting area of research by illustrating the power of hybrid methods to tack-le challenging mega systems and by identifying limitations and gaps in hybrid methods as currently practiced. The Workshop is based on the emerging concepts that (1) macromolecular assemblies and machines represent the pivotal level in the structural hierarchy for most fundamental processes; and (2) these entities may be most effectively studied by appropriate combinations of experimental methods, i.e. "hybrid approaches." The Workshop will be held from March 12-16, 2008 at the Granlibakken Conference in Lake Tahoe, CA. Its program will consist of two keynote lectures, seven platform sessions with both invited talks (70%) and talks selected from submitted abstracts (30%), and two poster sessions. The platform session topics are as follows: Hybrid Approaches to Macromolecular Filaments; Hybrid Approaches to Membrane Complexes; Hybrid Approaches to Dynamic Assemblies, Computational Approaches to Hybrid Analysis; Hybrid Approaches Macromolecular Machines; Hybrid Approaches to Cellular Organization, and Cellular Proteomics. Drs. D. Hanein and W. Sundquist serve as Chairs of the meeting and Drs. A. Steven, B. Geiger, C.M. Waterman-Storer, R.M. Stroud, W. Baumeister are members of the organizing committee. The Workshop will be extensively advertised and will be as inclusive and diversity-sensitive as the organizers can achieve and the 150-participant limit will allow.