Photoacoustic Micro-Imaging system for Shared Tumor Imaging Resource at Roswell P

描述(由申请人提供)：本NCRR共享仪器赠款申请的目的是获得资金，为罗斯韦尔公园癌症研究所(RPCI)的共享肿瘤成像资源(STIR)购买一台小动物光声成像系统(Vevo(R)LAZR)。RPCIA的STIR以服务费的形式向RPCINIH资助的研究人员、纽约州立大学布法罗分校(SUNY-Buffalo)和邻近的纽约西部学术机构提供定制的科学和技术小动物成像服务。自2005年以来，STIR的使用率稳步增长，这是因为人们对其成像技术的认识有所提高，这是通过与机构教职员工的积极合作以及STIR和RPCI制定的教育推广计划实现的。然而，这一积极的变化也突显了对最先进的成像技术的需求，以满足RPCI研究界不断扩大的需求。Vevo LAZR平台是专门为小动物高分辨率成像而设计的高灵敏度系统。此外 为了对肿瘤进行解剖或形态评估，该系统允许在疾病的小动物模型中对肿瘤微环境进行分子功能成像。复杂的软件平台允许以高效和用户友好的方式对成像数据集进行可视化和定量分析。随着人们对癌症的个性化药物和分子靶向治疗的兴趣与日俱增，美国国立卫生研究院资助的几个项目在RPCI和纽约州立大学水牛城分校专注于了解肿瘤在恶性进展和后续治疗过程中微环境的变化。这些项目，其中一些已在本申请中详细说明，将利用Vevo(R)LAZR系统：(I)在 其主要功能包括：(1)测量肿瘤的病变部位，如肾脏和肝脏；(2)评估治疗后肿瘤形态的纵向变化；(3)可视化和量化肿瘤血流量的变化；(4)绘制前哨淋巴结和淋巴管的图谱；(5)测量肿瘤中的氧合和血红蛋白饱和度等参数；(6)研究多功能纳米颗粒的肿瘤靶向能力。在STIR上提供用户友好的便携式成像系统将使其用户能够有效地将高通量解剖成像与肿瘤的定量、功能分子成像结合在一起。收购光声成像系统不仅将使STIR满足现有对该成像技术的需求，还将通过增加其可供研究人员使用的成像服务和技术，促进STIR的进一步发展。 公共卫生相关性：罗斯威尔公园癌症研究所(RPCI)的共享肿瘤成像资源需要一个高分辨率、高灵敏度的光声成像系统。用户友好的便携式成像系统的可用性将使RPCINCI/NIH资助的多名研究人员能够有效地将高通量解剖成像与定量、功能分子成像结合起来，用于癌症研究应用。

DESCRIPTION (provided by applicant): The purpose of this NCRR Shared Instrument Grant application is to secure funding to purchase a Small Animal Photoacoustic Imaging system (Vevo(R)LAZR) for the Shared Tumor Imaging Resource (STIR) at Roswell Park Cancer Institute (RPCI). The STIR at RPCI provides customized scientific and technical small animal imaging services on a fee for service basis to NIH funded investigators at RPCI, the State University of New York at Buffalo (SUNY-Buffalo) and neighboring academic institutions in Western New York. Since 2005, the STIR has seen a steady growth in its utilization as a result of increased awareness of its imaging technologies achieved through active collaborations with institutional faculty and educational outreach programs instituted by STIR and RPCI. However, this positive change has also highlighted the need for state- of-the-art imaging technology to meet the expanding needs of RPCI research community. The Vevo LAZR platform is a high sensitivity system specifically designed for small animal imaging at a high resolution. In addition to anatomic or morphologic assessment of tumors, the system allows for molecular functional imaging of the tumor microenvironment in small animal models of disease. The sophisticated software platform allows for visualization and quantitative analysis of imaging datasets in an efficient and user-friendly manner. With the increased interest in personalized medicine and molecular targeted therapies for cancer, several NIH-funded programs at RPCI and SUNY-Buffalo are focused on understanding the changes in the tumor microenvironment during malignant progression and following therapy. These projects, some of which have been detailed in this application, will utilize the Vevo(R)LAZR system to (i) detect occult metastatic lesions in disease sites such as the kidney and liver, (ii) assess longitudinal changes in tumor morphology following treatment, (iii) visualize and quantify changes in tumor blood flow, (iv) map sentinel lymph nodes and lymphatics, (v) measure parameters such as oxygenation and hemoglobin saturation in tumors, and, (vi) investigate tumor-targeting ability of multifunctional nanoparticle. The availability of a user-friendly, portable imaging system at STIR would enable its users to effectively combine high-throughput anatomic imaging with quantitative, functional molecular imaging of tumors. Acquisition of the photoacoustic imaging system will not only enable STIR to meet the existing demand for this imaging technology but also facilitate further growth of STIR by increasing its imaging services and technologies available to researchers. PUBLIC HEALTH RELEVANCE: A high-resolution, high sensitivity photoacoustic imaging system is requested for the Shared Tumor Imaging Resource at Roswell Park Cancer Institute (RPCI). The availability of a user-friendly, portable imaging system would enable multiple NCI/NIH-funded investigators at RPCI to effectively combine high throughput anatomic imaging with quantitative, functional molecular imaging for cancer research applications.