SOCIAL HOUSING AND SIV DISEASE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 导论. 如果对非人灵长类动物的管理考虑到它们的疾病状况，那么可以为生物医学研究中使用的非人灵长类动物提供最好的生活质量。 例如，重要的是要了解如何最好地满足灵长类动物的社会需求，在整个猴免疫缺陷病毒疾病的进展。 本研究的目的是：1）描述与猴免疫缺陷病毒疾病进展相关的心理健康变化，2）确定健康指标与疾病相关生理变化之间的对应关系，3）确定任何阈值行为或生理值，这些值应用于触发对研究对象的兼容性或社会环境变化的增加审查。 方法. 受试者包括被分配到涉及SIV感染和预期SIV疾病发展的研究方案（即不接受疫苗、其他预防措施或实验性治疗）的成年印度恒河猴。 研究的受试者总数为每种性别32例。 使用行为、生理、免疫和临床数据，评估个体内的变化。 此外，正在比较成对与单个外壳的效果。 录像数据收集在社会引入和SIV接种之前开始，以记录单个饲养中的基线概况，并在引入成对饲养后和感染前重复。 在配对中，两个成员在同一天接种。 接种后，第一个月集中收集数据。 第一个月后，遵循不太密集的数据收集的稳定时间表，直到达到动物护理和使用委员会批准的终点。 结果/讨论。 12只动物达到研究终点，已启动数据编码。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Introduction. Nonhuman primates used in biomedical research can be provided the best quality of life if their management takes their disease status into consideration. For example, it is important to understand how to best meet the social needs of primates throughout the progression of the Simian Immunodeficiency Virus disease. This study aims to 1) characterize the changes in psychological wellbeing associated with Simian Immunodeficiency Virus disease progression, 2) determine the correspondence between measures of wellbeing and disease-related changes in physiology, and 3) identify any threshold behavioral or physiological values that should be used to trigger either increased scrutiny of compatibility or alterations in the social setting of research subjects. Methods. Subjects include adult, Indian-origin rhesus macaques assigned to research protocols involving SIV infection and anticipated development of SIV disease (i.e. not subject to vaccines, other prophylactic measures, or experimental treatments). The total number of subjects studied will be 32 of each sex. Using behavioral, physiological, immunological and clinical data, changes within individuals are assessed. In addition, effects of pair- versus single housing is being compared. Videotaped data collection begins prior to social introduction and SIV inoculation in order to document baseline profiles in single housing, and is repeated after introduction into pair housing and prior to infection. Within pairs, both members are inoculated on the same day. After inoculation, data are collected intensively for the first month. After the first month, a steady scheduling of less intensive data collection is followed until the endpoints approved by the Animal Care and Use Committee are reached. Results/Discussion. Twelve animals reached study endpoints and data coding has been initiated.