SPECTROSCOPIC STUDIES OF NITRIC OXIDE SYNTHASE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 一氧化氮合酶家族是开发新药的关键目标，用于治疗目前缺乏有效治疗的多种疾病，包括中风、感染性休克、高血压和癌症。然而，由于对一氧化氮合酶调节的分子机制尚不完全了解，目前尚未有一氧化氮合酶抑制剂用于临床治疗。建议的研究将显著提高对一氧化氮合酶调控的基本了解，并有可能促进以生物理性为基础的新的选择性机制药物实体的开发，以针对这些临床上重要的一氧化氮合酶亚型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The NOS family is a key target for development of new pharmaceuticals for a wide range of diseases that currently lack effective treatments including stroke, septic shock, hypertension and cancer. However, due to an incomplete understanding of the molecular mechanisms of NOS regulation, NOS inhibitors have not yet been available for clinical treatments. The proposed studies will significantly improve the fundamental understanding of NOS regulation, and has the potential of facilitating bio-rational development of new selective mechanism-based drug entities to target these clinically important NOS isoforms.