EVALUATION OF QUALITY OF MACROMOLECULAR CRYSTALS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 BioCARS正在提供晶体评估会议，在这种会议上，波束时间在短时间内分配给当地用户团体，以测试和评估他们的新晶体。任何结晶学项目的关键部分都是对晶体质量和新的晶体形态进行优化和评估。这一过程通常是在家庭机构的旋转阳极上费力地完成的。我们建议继续在14区提供这样的评估。非常强的同步加速器X射线源提供了重要的优势：它大大加快了获得的衍射图像的过程，提供了更好的晶体质量指示，并使测试小的或弱的衍射晶体成为可能。 事实证明，我们以前的评估会议对当地用户非常受欢迎和有价值。我们只向已经注册并接受过当前培训的APS用户提供这些课程，因此根据这项建议收集的一些数据也可以与其他一般用户建议相关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. BioCARS is offering crystal evaluation sessions where beamtime is allocated on a short notice to local user groups to test and evaluate their new crystals. A critical part of any crystallographic project is optimization and evaluation of crystal quality and new crystal forms. This process is usually painstakingly done on a rotating anode at the home institution. We propose to continue with offering such evaluation at the Sector 14. Very intense synchrotron X-ray source provides important advantages: it greatly speeds up the process obtained diffraction images provide better indication of crystal quality and testing of small or weakly diffracting crystals becomes possible. Our previous evaluation sessions have proven very popular and valuable to local users. We are offering these sessions only to already registered APS users with current training so some of the data collected under this proposal could also be associated with other general user proposals.