Mayo Alzheimer's Disease Research Center

梅奥阿尔茨海默病研究中心（ADRC）位于明尼苏达州罗切斯特市和佛罗里达州杰克逊维尔市，将研究两个主题：1)从衰老到阿尔茨海默病（AD）认知谱系早期阶段受试者的招募和表征，特别是关注轻度认知障碍（MCI）； 2)非阿尔茨海默病痴呆（包括额颞叶变性和路易体痴呆）的研究。ADRC将由5个核心组成：行政核心、临床核心、数据管理与统计核心、神经病理学核心和教育与信息传递核心。这些核心将相互作用，并将支持三个拟议的研究项目：1)识别痴呆症与路易体和AD的多模态成像相关性，2)阿尔茨海默病和神经退行性疾病的PGRN/TDP-43轴，以及3)通过基因表达全基因组关联鉴定AD风险变异。核心研究将由该领域的知名研究人员领导，三个项目将由在各自研究领域经验丰富、富有成效的年轻研究人员指导，这些研究人员过去没有担任过项目负责人。这三个人都在ADRC的环境中接受了痴呆症研究方面的杰出研究人员的培训，他们将继续探索成熟的研究主题。在目前的拨款周期中，研究中心的工作人员已出版了340种出版物、70章和276篇摘要，并将在拟议的拨款周期中继续保持这种生产力。该中心将继续其关于UDS的工作，并为NACC数据库作出贡献。通过核心和项目之间的密切合作，MCI，神经影像学和临床病理相关性的研究将继续进行。ADRC也将继续成为年轻调查人员的培训平台。

The Mayo Alzheimer's Disease Research Center (ADRC) is located in Rochester, MN and Jacksonville, FL and will pursue two themes: 1) The recruitment and characterization of subjects in the early stages of the cognitive spectrum from aging to Alzheimer's disease (AD) particularly focusing on mild cognitive impairment (MCI), and 2) the study of non-AD dementias including frontotemporal lobar degeneration and dementia with Lewy bodies. The ADRC will consist of 5 cores: Administrative Core, Clinical Core, Data Management and Statistics Core, Neuropathology Core and Education and Information Transfer Core. The cores will interact with each other and will support three proposed research projects: 1) Identifying Multi-modality Imaging Correlates of Dementia with Lewy Bodies and AD, 2) The PGRN/TDP-43 Axis in Alzheimer's Disease and Neurodegeneration, and 3) Identification of AD Risk Variants by Genome Wide Association of Gene Expression. The cores will be led by established investigators in the field and the three projects will be directed by younger but experienced and productive investigators in their respective areas of research who have not been project leaders in the past. All three were trained in the ADRC environment by prominent investigators in dementia research and they will continue to explore well-established research themes. The ADRC staff has produced 340 publications, 70 chapters and 276 abstracts in the current grant cycle and will continue this productivity in the proposed grant cycle. The Center will continue its work on the UDS and contribute to the NACC database. Research on MCI, neuroimaging and clinical-pathological correlations will continue through the intense collaboration among the cores and projects. The ADRC will also continue to be a training platform for young investigators.