课题基金 / 基金详情

Effect of molecular oxygen on cardiovascular and cancer biology

Effect of molecular oxygen on cardiovascular and cancer biology
分子氧对心血管和癌症生物学的影响
批准号：
8558000
负责人：
PAUL M. HWANG
金额：
$66.82万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8558000
关键词：
Adverse effectsAffectBiologyCancer BiologyCardiovascular systemClinicalDNA DamageDevelopmentEmployee StrikesGenomic InstabilityGenomicsHealthHypoxiaKnockout MiceLong-Term EffectsMolecularMonitorOxidative StressOxygencancer preventioninsightmitochondrial dysfunctionoxidative DNA damagetumorigenesis

项目摘要

项目成果

PAUL M. HWANG的其他基金

相似基金

相关文献

中文摘要
翻译
我们目前的研究表明，线粒体功能障碍导致与氧相关的基因组DNA损伤。由于氧是氧化应激（基因组不稳定的一个原因）的重要因素，我们一直在研究调节环境氧对新生肿瘤发生的影响。我们发现，减少p53缺失小鼠的环境氧暴露可显著延缓肿瘤发生。我们正在进一步调查这一现象。由于已知缺氧会影响心血管系统，我们正在监测其对心血管健康的影响，以寻找潜在的副作用。这些研究可能为环境氧调节如何影响肿瘤发生过程提供见解，并具有临床意义。
英文摘要
Our current studies suggest mitochondrial dysfunction causes oxygen-associated genomic DNA damage. Because oxygen serves as an essential factor for oxidative stress, a cause of genomic instability, we have been examining the effect of modulating ambient oxygen on de novo tumorigenesis. We have found that decreasing the ambient oxygen exposure of p53 null mice causes a striking delay in tumorigenesis. We are now investigating this phenomenon in further detail. As hypoxia is known to affect the cardiovascular system, we are monitoring its effect on cardiovascular health for potential side-effects. These studies may provide insights into how modulation of ambient oxygen affects the course of tumorigenesis and have clinical implications.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Effects of redox homeostasis on cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
海外基金