Marietta Community Actively Researching Exposure Study

项目摘要 锰是一种必需元素，但过量则具有神经毒性。尽管事实是 婴儿和幼儿患锰神经毒性的风险可能比成年人更大， 很少有研究评估慢性锰暴露对儿童的影响 发展。俄亥俄州的玛丽埃塔，阿巴拉契亚的一个农村社区，一直是 50多年来，只有美国和加拿大的金属精炼厂。作为回应，社区 形成了清洁空气(NCA)的邻居。辛辛那提大学(UC)已经 NCA要求帮助他们了解其暴露和相关的健康影响， 如果有的话。为了这个项目，Marietta社区积极研究暴露研究 (CARE)，社区定义了研究议程，确定了研究 问题、目标、具体目标和确定可用的资源 社区进行这项研究。社区成员将参与所有 研究项目的各个方面，包括环境采样、神经行为 评估、项目协调和生物标本收集。初级阶段 这项应用的目的是检查锰暴露的生物学指标在 并了解慢性接触锰对儿童的影响。统一通信将 提供环境健康研究方面的培训、监督和专业知识，以解决 以下假设：儿童早期接触锰显著 7-8岁高暴露儿童的神经发育缺陷 与年龄匹配的低/未暴露组相比。为了检验这一假设， 遵循社区驱动的具体目标将会实现。具体目标1：评估 在高锰暴露社区、俄亥俄州马里埃塔和a 低锰暴露社区，剑桥，俄亥俄州。具体目标2：评估比较 高锰暴露对儿童神经行为的影响 俄亥俄州玛丽埃塔的社区和俄亥俄州剑桥的低锰暴露社区。特定的 目的3：评价接触锰对儿童神经运动影响的比较 暴露社区，俄亥俄州玛丽埃塔和低锰暴露社区，剑桥， 俄亥俄州。鉴于儿童对毒物暴露的独特敏感性，以及 在长期暴露的社区中研究锰暴露的机会，我们预计这是 重大影响地方和国家与疟疾有关的公共卫生政策的项目 曝光。项目叙事 暴露于锰(Mn)会导致神经缺陷，以下是 全球接触MMT形式的锰的巨大潜力，MMT是一种抗爆剂，可用于 更换汽油中的铅。玛丽埃塔社区积极研究暴露研究 (CARE)是一项以社区为基础的研究，旨在探索长期的健康影响 儿童的锰暴露。

Project Summary Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child development. Marietta, Ohio, a rural Appalachian community, has been home to the only metal refinery in the US and Canada for over 50 years. In response, the community formed Neighbors for Clean Air (NCA). The University of Cincinnati (UC) has been asked by NCA to assist them in understanding their exposure and related health effects, if any. For this project, Marietta Community Actively Researching Exposure Study (CARES), the community has defined the research agenda, determining the research questions, objectives, specific aims and identifying resources available within the community to conduct the research. Members of the community will be engaged in all facets of the research project, including environmental sampling, neurobehavioral assessment, project coordination, and collection of biological specimens. The primary objectives of this application are to examine biological indicators of Mn exposure in children and understand the effects of chronic manganese exposure in children. UC will provide training, oversight and expertise in environmental health research, to address the following hypothesis: Exposure to Mn during early childhood is significantly associated with neurodevelopmental deficits in high exposed children ages 7-8 years compared to an age matched low/unexposed group. In order to test the hypothesis, the following community-driven specific aims will be accomplished. Specific Aim 1: Assess environmental Mn exposure within a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 2: Evaluate comparisons of the neurobehavioral effects in children exposed to Mn in a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 3: Evaluate comparisons of the neuromotor effects in children exposed to Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Given the unique susceptibility of children to toxicant exposure and the opportunity to study Mn exposure in a chronically exposed community, we anticipate this project to significantly impact local and national public health policy related to Mn exposure. Project Narrative Exposure to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children.