perfluorooctanoic acid in laboratory animals for the National Toxicology Program

本项目的目的是评估全氟辛酸（PFOA）在大鼠饮食中暴露的慢性毒性和致癌性。全氟辛酸作为表面活性剂用于泡沫灭火剂以及不粘和防污产品的生产，在环境中具有持久性。2-慢性毒性和致癌性研究处于组织病理学/报告编写阶段。这些研究包括围产期接触（妊娠期和哺乳期接触）。人类可能通过环境类似地暴露于这些化合物。围产期接触发生在发育的关键时期，与仅从成年期开始接触相比，可能导致毒性/致癌性的差异。PFOA研究包括有和没有围产期暴露的2年暴露，以评估围产期暴露的影响。 关键词：毒性，致癌性，围产期，全氟辛酸

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of perfluorooctanoic acid (PFOA) in rats exposed in the diet. PFOA is used as a surfactant in foam fire-fighting agents and in the production of non-stick and stain-resistant products and is persistent in the environment. 2-Year chronic toxicity and carcinogenicity studies are in the histopathology/report writing phase. These studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. The PFOA studies include 2-year exposures in both with and without perinatal exposure, to evaluate the effect of perinatal exposure. Keywords: toxicity, carcinogenicity, perinatal, perfluorooctanoic acid