Predoctoral Training in Pharmacological Sciences

描述（由申请人提供）：此资助提案重新提交寻求支持一个非常成功的博士前药理学培训计划在威尔康奈尔大学医学研究生院（WCGSMC），已完成了最初的五年期的资金由NIGMS。WCGSMS的药理学培训计划是跨部门和跨机构的，由来自威尔康奈尔医学院和斯隆-凯特琳研究所的杰出研究人员组成。这些机构提供了一个非常丰富的研究环境，包括最先进的仪器和核心设施，慷慨的空间分配给药理学计划，并继续致力于招募最聪明和最好的新教师。这些机构都为发展其生物医学研究项目做出了重大贡献，未来五年的成本超过13亿美元。参与的27名教师是一个由世界一流研究人员组成的有凝聚力的团队，在培养未来的科学领导者和学者方面拥有良好的记录。在过去的五年中，我们的教师培训师团队已经扩大，增加了六个新的培训实验室，包括几个初级教师实验室。一个主要 该计划的重点是与学员分享发现的兴奋，培养学生的批判性推理能力，并灌输学生成为有效的生物医学研究人员所需的所有技能。在过去的10年里，我们的TG教师共同为191名异常富有成效的博士前学员的发展做出了贡献。我们的教师导师高度合作，具有不同的研究兴趣-他们为学员提供广泛的研究机会，在转化生物医学，心血管药理学，神经药理学，癌症生物学，细胞信号传导，代谢，化学生物学，合成化学，计算生物学和结构生物学领域。该计划通常每年招收10-12名优秀的博士前学生，其中8- 10名符合培训条件。例如，我们最近入学的班级由11名学生组成，其中10名符合培训条件-这个班级的平均GPA为3.48，平均GRE成绩为H 80百分位。招收的学生通常获得美国顶尖大学的本科学位，并有重要的本科研究经验。目前，我们有69名博士前学生在培训，不算一组额外的MD/博士。在这69名博士生中，57名符合培训条件，5名来自代表性不足的少数民族（URM）或身体残疾。在我们最初的五年资助期间，这个TG将支持14名优秀的博士前学生在10名不同教师的实验室中进行培训; 2/14的受训人员来自URM或身体残疾团体。本申请寻求对药理科学有效的博士前培训计划的持续增长的支持。 公共卫生相关性：这项拨款提案旨在为希望在威尔康奈尔医学院和斯隆-凯特琳研究所联合主办的顶级药理学项目中接受培训的优秀博士生提供持续的奖学金支持。我们的教师是一群富有成效的生物医学研究人员，他们共同致力于培养下一代科学家，创造创新疗法，改善我们的世界。

DESCRIPTION (provided by applicant): This grant proposal resubmission seeks support for a highly successful predoctoral Pharmacology Training Program at the Weill Cornell Graduate School of Medical Sciences (WCGSMC) that has completed an initial five-year period of funding by NIGMS. The Training Program in Pharmacological Sciences at WCGSMS is inter-departmental and inter-institutional, comprising a faculty of distinguished investigators assembled from the Weill Cornell Medical College and Sloan-Kettering Institute. These institutions provide an exceedingly rich research environment, including state-of-the-art instrumentation and core facilities, a generous space allocation to the Pharmacology Program and a continuing commitment to recruiting the brightest and best new faculty. Each of these institutions has made a major contribution to growing their biomedical research programs, at a cost of > $1.3 billion over the next five years. The twenty-seven participating faculty are a cohesive group of world-class investigators with solid records for training future scientific leaders and scholars. During the past five years, our group of faculty trainers has been expanded with the addition of six new training labs, including several junior faculty labs. A major emphasis of the Program is to share the excitement of discovery with trainees, cultivate the student's capacity for critical reasoning, and instill in students all necessary skills to become effective biomedical researchers. Together, our TG faculty has contributed to the development of 191 unusually productive predoctoral trainees during the past 10 years. Our faculty mentors are highly-collaborative and have diverse research interests - they provide trainees with broad research opportunities in the areas of translational biomedicine, cardiovascular pharmacology, neuropharmacology, cancer biology, cell signaling, metabolism, chemical biology, synthetic chemistry, computational biology and structural biology. The Program typically enrolls 10-12 outstanding predoctoral students annually, including 8- 10 that training-eligible. For example, our recent entering class was comprised of 11 students, of which 10 are training-eligible - this class had a mean GPA of 3.48 and mean GRE scores of H 80 percentile. Recruited students typically receive undergraduate degrees from top universities in the USA and have had significant undergraduate research experiences. Currently, we have 69 predoctoral students in training, not counting an additional group of MD/PhDs. Among this group of 69 PhD-only predoctoral trainees, 57 are training eligible and 5 are from underrepresented minorities (URM) or physically-disabled. During our initial five years of funding, this TG will have supported the training of 14 outstanding predoctoral students in labs of 10 different faculty members; 2/14 trainees were from URM or physically disabled groups. This application seeks support for the continued growth of an effective predoctoral Training Program in the Pharmacological Sciences. PUBLIC HEALTH RELEVANCE: This grant proposal seeks support for the continued fellowship support for outstanding PhD students who wish to train in a top-tier Pharmacology Program, hosted jointly by the Weill Cornell Medical College and Sloan-Kettering Institute. Our faculty is a group of highly productive biomedical researchers who share the aspiration to develop the next generation of scientists and create innovative therapies that will better our world.