Predoctoral Training in Pharmacological Sciences

描述（由申请人提供）：本拨款提案再次提交，旨在支持威尔康奈尔医学科学研究生院（WCGSMC）的一个非常成功的博士前药理学培训项目，该项目已经完成了NIGMS最初的五年资助期。WCGSMS的药理学培训计划是跨部门和跨机构的，由来自威尔康奈尔医学院和斯隆凯特林研究所的杰出研究人员组成。这些机构提供了极其丰富的研究环境，包括最先进的仪器和核心设施，为药理学项目提供了慷慨的空间分配，并继续致力于招募最聪明、最优秀的新教师。这些机构中的每一个都为发展其生物医学研究项目做出了重大贡献，在未来五年内将耗资130亿美元。27名参与研究的教师组成了一个具有凝聚力的世界级研究团队，在培养未来的科学领袖和学者方面有着坚实的记录。在过去的五年中，我们的教师培训师团队已经扩大，增加了六个新的培训实验室，包括几个初级教师实验室。一个主要

DESCRIPTION (provided by applicant): This grant proposal resubmission seeks support for a highly successful predoctoral Pharmacology Training Program at the Weill Cornell Graduate School of Medical Sciences (WCGSMC) that has completed an initial five-year period of funding by NIGMS. The Training Program in Pharmacological Sciences at WCGSMS is inter-departmental and inter-institutional, comprising a faculty of distinguished investigators assembled from the Weill Cornell Medical College and Sloan-Kettering Institute. These institutions provide an exceedingly rich research environment, including state-of-the-art instrumentation and core facilities, a generous space allocation to the Pharmacology Program and a continuing commitment to recruiting the brightest and best new faculty. Each of these institutions has made a major contribution to growing their biomedical research programs, at a cost of > $1.3 billion over the next five years. The twenty-seven participating faculty are a cohesive group of world-class investigators with solid records for training future scientific leaders and scholars. During the past five years, our group of faculty trainers has been expanded with the addition of six new training labs, including several junior faculty labs. A major emphasis of the Program is to share the excitement of discovery with trainees, cultivate the student's capacity for critical reasoning, and instill in students all necessary skills to become effective biomedical researchers. Together, our TG faculty has contributed to the development of 191 unusually productive predoctoral trainees during the past 10 years. Our faculty mentors are highly-collaborative and have diverse research interests - they provide trainees with broad research opportunities in the areas of translational biomedicine, cardiovascular pharmacology, neuropharmacology, cancer biology, cell signaling, metabolism, chemical biology, synthetic chemistry, computational biology and structural biology. The Program typically enrolls 10-12 outstanding predoctoral students annually, including 8- 10 that training-eligible. For example, our recent entering class was comprised of 11 students, of which 10 are training-eligible - this class had a mean GPA of 3.48 and mean GRE scores of H 80 percentile. Recruited students typically receive undergraduate degrees from top universities in the USA and have had significant undergraduate research experiences. Currently, we have 69 predoctoral students in training, not counting an additional group of MD/PhDs. Among this group of 69 PhD-only predoctoral trainees, 57 are training eligible and 5 are from underrepresented minorities (URM) or physically-disabled. During our initial five years of funding, this TG will have supported the training of 14 outstanding predoctoral students in labs of 10 different faculty members; 2/14 trainees were from URM or physically disabled groups. This application seeks support for the continued growth of an effective predoctoral Training Program in the Pharmacological Sciences.