CORE FACILITY FOR AGED RODENTS

CFAR，老年啮齿动物的核心设施，一直是密歇根大学克劳德大学的一大特色 花椒中心自成立以来一直在。CFAR将继续服务于胡椒中心的需求 调查人员通过四个具体目标。(1)CFAR将向OAIC的所有调查人员提供建议，从 学生通过教职员工水平，利用啮齿动物研究衰老及其在生物学中的作用 生命疾病。(2)CFAR将支持专门的小鼠群体，特别适合研究 衰老生物学及其与老年疾病的关系。这些包括(A)遗传异质性的小鼠 UM-HET3小鼠；(B)热量受限的UM-HET3小鼠；以及(C)长寿的Snell侏儒小鼠 (dw/dw)股票，携带Pitl dw突变。来自这些群体的老鼠将被提供给教职员工 参与PESC和RCDC研究项目，以及希望 在其他NIA资金来源的支持下，开展关于小鼠衰老的试点研究。(3)CFAR资金将支持 为特定目的开发新的动物模型。在第一年，这些将包括一个新的Fourway CROSS适合研究晚年听力损失，CAG-Repeat敲入小鼠研究计时 与年龄相关的运动神经元病。(4)透过CORE培育以啮齿动物为本的新研究项目 发展项目。在第一年，将支持两个这样的项目，一个是开发仪器 用于评估年龄相关的平衡和前庭功能的变化，另一种用于卡路里 限制和矮小小鼠评估衰老和抗衰老干预在皮肤细胞增殖中的作用 以及促进肿瘤的转变。CFAR主任还将在帮助开发和设计 利用啮齿动物模型的RCDC和PESC项目。

CFAR, the Core Facility for Aged Rodents, has been a major feature of the University of Michigan Claude Pepper Center since its inception in 1989. CFAR will continue to serve the needs of Pepper Center investigators through four Specific Aims. (1) CFAR will provide advice to all OAIC investigators, from student through faculty levels, in the use of rodents for research into the biology of aging and its role in late life disease. (2) CFAR will support specialized colonies of mice particularly well suited for research on the biology of aging and its relationship to late-life disease. These include (a) genetically heterogeneous mice of the UM-HET3 stock; (b) calorically restricted UM-HET3 mice; and (c) mice of the long-lived Snell dwarf (dw/dw) stock, carrying the Pitl dw mutation. Mice from these colonies will be provided to faculty members working on PESC and RCDC research projects, as well as to Geriatrics Center faculty members who wish to conduct pilot studies on mouse aging supported by other sources of NIA funds. (3) CFAR funds will support the development of new animal models for specific purposes. In the first year, these will include a new fourway cross suitable for studies of late-life hearing loss, and a CAG-repeat knock-in mouse to study the timing of age-dependent motor neuron disease. (4) To nurture new rodent-based research initiatives through Core Development Projects. In the first year two such projects will be supported, one to develop instrumentation for assessment of age-dependent changes in balance and vestibular function, and the other to use calorically restricted and dwarf mice to evaluate the role of aging and anti-aging interventions in skin cell proliferation and pro-neoplastic transformation. The CFAR director will also play a role in helping to develop and design RCDC and PESC projects that make use of rodent models.