perfluorooctanoic acid in laboratory animals for the National Toxicology Program

本项目旨在评估全氟辛酸（PFOA）对大鼠的慢性毒性和致癌性。PFOA在泡沫灭火剂和生产不粘、耐污产品中用作表面活性剂，在环境中具有持久性。2年慢性毒性和致癌性研究报告目前正在定稿。这些研究包括围产期暴露（妊娠和哺乳期暴露）。人类很可能同样通过环境接触到这些化合物。围产期接触发生在发育的关键时期，与仅从成年期开始接触相比，可能导致毒性/致癌性的差异。PFOA研究包括围产期暴露和不围产期暴露的2年暴露，以评估围产期暴露的影响。

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of perfluorooctanoic acid (PFOA) in rats exposed in the diet. PFOA is used as a surfactant in foam fire-fighting agents and in the production of non-stick and stain-resistant products and is persistent in the environment. Reports for the 2-Year chronic toxicity and carcinogenicity studies currently being finalized. These studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. The PFOA studies include 2-year exposures in both with and without perinatal exposure, to evaluate the effect of perinatal exposure. Keywords: toxicity, carcinogenicity, perinatal, perfluorooctanoic acid