Head and Neck Oncology

头颈肿瘤学计划(HNOP)是头颈部癌症研究的综合计划，包括基础、临床、行为、人口和转化性研究的多学科研究团队。该项目由来自密歇根大学五所学校11个系的44名成员组成。HNOP的直接成本资助在这一赠款期间增加了60%，达到500多万美元，其中2美元是NCI资助，包括头颈孢子。在这一赠款期间，计划成员发表了293篇论文，其中22.5%展示了计划内合作，33.4%展示了计划间合作。该计划的许多成员也是其他癌症中心基础科学或预防计划的联合成员，这些计划将额外的基础研究整合到头颈部癌症行为和治疗的潜在机制中。 HNOP的主要研究主题是： 1.确定癌症发生和发展的机制 2.确定治疗反应的分子决定因素 3.描述肿瘤微环境的免疫生物学特征，以更好地调节免疫系统作为一种治疗方式 4.描述肿瘤干细胞在肿瘤进展、侵袭、转移和耐药中的作用 5.根据实验室和临床研究确定新的治疗组合，为个体化治疗定义新的生物标志物 6.确定头颈部癌症的器官保护策略 7.为头颈部癌症患者开发和实施新的重建和康复技术 在这段时间里，这个项目经历了大量的招聘，有18名新的教员，并重新/扩大了对翻译研究的重视，这应该会在下一个资助周期完全实现。

The Head and Neck Oncology Program (HNOP) is a comprehensive program in head and neck cancer research that includes a multidisciplinary team of Investigators In basic, clinical, behavioral, population and translational research. The program consists of 44 members from 11 departments in five schools across the University of Michigan. The HNOP's direct cost funding has increased by 60% over this grant period, to over $5 million of which $2 is in NCI funding, including a Head and Neck SPORE. Program members published 293 papers during this grant period, 22.5% of which demonstrated intra-programmatic and 33.4% Inter-programmatic collaborations. Many members of this program also hold joint membership in other Cancer Center basic science or prevention programs which integrate additional fundamental research into the underlying mechanisms of head and neck cancer behavior and treatment. The major research themes of the HNOP are to; 1. Identify mechanisms of carcinogenesis and progression 2. Determine the molecular determinants of treatment response 3. Characterize the immunobiology of the tumor microenvironment to better modulate the immune system as a therapeutic modality 4. Characterize the role of cancer stem cells in tumor progression, Invasion, metastasis and resistance to treatment 5. Define new treatment combinations based on laboratory and clinical studies that define new biomarkers for individualized therapies 6. Define organ preservation strategies in head and neck cancer 7. Develop and implement novel reconstruction and rehabilitation techniques for head and neck cancer patients This program has undergone considerable recruitment over this grant period with 18 new faculty members, and a renewed/expanded emphasis on translational research that should become fully realized over the next grant cycle.