Neurobiological Mechanisms Underlying the Symptoms and Course of Schizophrenia

描述(由申请人提供)：这是加州大学旧金山分校精神病学系的一份机构培训补助金(T32)的申请。我们建议对新近的医学博士、博士和医学博士/博士进行培训，用来研究精神分裂症症状及其神经发育和神经退化过程的神经生物学机制。以症状为导向的方法避免了与精神分裂症作为诊断的异质性相关的问题；神经科学方法使我们能够更接近导致症状的基础和机制；疾病病程方法使我们能够解决可能的预防、干预和治疗。这些方法反映了拟议的T32教员的研究兴趣和专业知识。研究：我们充分利用了精神病学学院的成员，他们使用神经科学的方法，包括人类和非人类物种，来理解精神分裂症的许多表现。每个学员在第一年做一个导师发起的项目，在第二年做一个自我发起的项目，这两个项目都会在地方、国家和国际生物精神病学会议上产生论文、海报和平台演讲。教育：学员将参加我们为期一年的每周T32研讨会系列和为期一年的神经科学精神病学课程；参加由学员和导师确定的加州大学旧金山分校的正式课程；以及参加每年一次的负责任研究行为课程。学员将每周与他们的研究导师见面，每月与他们的职业导师会面。培训：受训者将在研究和职业导师的双重指导下，正式和非正式地指导他们，学习神经生物学方法，产生大量数据，在全国会议上介绍数据，撰写和出版论文，准备赠款提案，并参加关于启动和维持生物精神病学成功职业的地方和国家研讨会。T32学院包括基础神经学家和精神病学家，从事遗传学、脑成像、电生理学和神经可塑性方面的工作。T32学院的每一位成员都将担任不同学员的研究和职业指导。T32将由朱迪思·福特博士指导，由执行委员会管理，执行委员会由福特博士、马塔隆博士、维诺格拉多夫博士、雷乌斯博士和巴伦德斯博士组成。除了第一年只有3名学员外，一次将有5名学员。

DESCRIPTION (provided by applicant): This is an application from the UCSF Department of Psychiatry for an Institutional Training Grant (T32). We propose to train recent MDs, PhDs, and MD/PhDs in methods used to study the neurobiological mechanisms underlying the symptoms of schizophrenia and its neuro-developmental and neuro- degenerative course. The symptom-oriented approach avoids issues associated with the heterogeneity of schizophrenia as a diagnosis; the neuroscience approach allows us to get closer to the substrates and mechanisms responsible for the symptom; the illness-course approach allows us to address possible prevention, intervention, and treatment. These approaches reflect the research interests and expertise of the proposed T32 faculty. Research: We have taken full advantage of the members of the Psychiatry Faculty who use neuroscience methods, with both human and non-human species, to understand schizophrenia, in its many manifestations. Each trainee will do a mentor-initiated project in the first year and a self-initiated project in the second, both resulting in papers, posters and platform talks at local, national, and international meetings on biological psychiatry. Education: Trainees will participate in our year-long integrative weekly T32 Seminar Series and our year- long Neuroscience in Psychiatry course; take formal UCSF courses identified by the trainee and mentor; and take yearly courses on the Responsible Conduct of Research. Trainees will meet with their Research Mentors weekly and Career Mentors, monthly. Training: Trainees will be dual-mentored with Research and Career Mentors to guide them both formally and informally, learning neurobiological methods, producing a body of data, presenting data at national meetings, writing and publishing papers, preparing grant proposals, and attending local and national workshops on launching and maintaining successful careers in biological psychiatry. The T32 Faculty includes basic neuroscientists and psychiatrists, working in genetics, brain imaging, electrophysiology, and neuroplasticity. Each member of the T32 Faculty will serve as Research and Career Mentors to different trainees. The T32 will be directed by Dr. Judith Ford and administered by the Executive Committee, comprised of Drs. Ford, Mathalon, Vinogradov, Reus and Barondes. Except during the first year, when there will be only three trainees, there will be 5 trainees at a time.