Experimental Irradiation

实验辐射核心供密歇根大学综合癌症中心(UMCCC)成员使用。这一核心的服务对于UMCCC的各种用户至关重要，例如那些对辐射生物学和辐射治疗感兴趣的用户，以及那些辐射为其提供研究工具的用户。因此，它服务于癌症中心的目标，鼓励基础研究以及翻译和临床应用。辐照核心负责维护和操作辐照器，并在项目启动前咨询每个调查员，咨询主任的经验和专业知识 和管理者允许他们向研究人员提供关于剂量和治疗方案的信息，特别是在动物研究中，以便以最佳方式利用实验资源。核心的另一个目标是通过连接在过去几年中在各种类型的实验中使用辐射的研究人员，促进核心用户之间的互动。用户的分布举例说明了癌症中心的各种成员对实验照射核心的使用。使用该核心的53名癌症中心成员参与了10个项目，包括乳腺肿瘤学、癌细胞生物学、实验治疗学、胃肠道肿瘤学和放射科学等。为了提供这项重要的服务，核心维护了4个辐射装置。2个正压单元(在医学科学I楼和生物医学科学大楼中)用于照射细胞培养物和动物(主要是小鼠和大鼠，但也可用于兔子和狗)。核心还维护一个小型动物辐照器，位于乌拉姆的小鼠住所的TINE特定病原体无区域。该装置的使用使调查人员能够在不将免疫缺陷小鼠从隔离设施中移走的情况下进行照射。这个 第四个照射器用于低剂量率(0.1-0.3GY/小时)照射。该辐射仪位于医学科学一号楼的放射肿瘤科内，内置一个加湿的二氧化碳孵化器，可用于研究长期暴露在极低辐射剂量率下的情况。CORE计划扩大其服务范围，为癌症中心成员提供用不同波长的紫外光照射细胞或DNA样本的机会。

The Experimental Irradiation core provides for the use of radiation by the members of the University of Michigan Comprehensive Cancer Center (UMCCC). The services of this core are critical to a variety of users in the UMCCC such as those Interested in radiation biology and radiation therapy, and those for whom radiation serves a research tool. Thus, it serves the goal of the Cancer Center to encourage basic research as well as translation and clinical applications. The irradiation core maintains and operates the irradiators and also consults with each investigator before initiation of a project, The experience and expertise of the director and manager allow them to offer Investigators Information on dosage and treatment regimens, particularly In animal studies, so that experimental resources are used In an optimal way. Another goal of the core is to foster Interactions between the users of the core by connecting investigators who have used radiation In various types of experiments over the last several years. Use of the Experimental Irradiation core by a variety of members of the Cancer Center is exemplified by the distribution of users. The 53 Cancer Center members who utilize the core participate In 10 Programs Including Breast Oncology, Cancer Cell Biology, Experimental Therapeutics, Gastrointestinal Oncology, and Radiation Sciences, among others. In order to provide this vital service, the core maintains 4 Irradiation devices. The 2 orthovoltage units (In the Medical Science I and Biomedical Science buildings) are used for irradiations of cell cultures and animals (primarily mice and rats but also available for use with rabbits and dogs). The core also maintains a small animal irradiator located In tine specific pathogen free area of the mouse housing in ULAM. The availability of this unit allows Investigators to perform Irradiations without removing immunodeficient mice from the quarantined facility. The fourth Irradiator Is for low dose rate (0.1-0.3 Gy/hour) irradiations. This irradiator, located within the Radiation Oncology department in the Medical Science I Building is built inside a humidified CO{2} Incubator, permitting studies of chronic exposure to very low radiation dose rates. The core is planning to expand Its services to also offer Cancer Center members the opportunity to Irradiate cell or DNA samples with ultraviolet light of different wavelengths.