Chemical and Structural Biology

对生物系统中分子功能的详细了解需要关于这三个方面的信息 大分子的空间结构。从结构研究中获得的丰富信息 生物学提供了对功能的新颖而强大的见解。化学生物学，蛋白质的调节 通过小分子发挥作用，既提供了探索生物功能的工具化合物，也为 治疗药物的开发。结构生物学和化学生物学的融合带来了 走到一起的两个群体说着相同的语言，这种语言的分子结构，使之合并 一种自然的组合。化学和结构生物学计划(CSB)将其总体目标定义为 促进这一对话，以促进对癌症的理解和治疗。公务员事务局关注这一目标 围绕四个主题：(1)以转录因子为靶标的结构和化学生物学。(2) 以信号分子为靶点的结构和化学生物学，(3)推进结构生物学技术， (4)用于成像、检测和诊断的化学生物学。约翰·H·布什韦勒，博士， 分子生理学和生物物理学，与凯文·R·林奇教授共同领导该项目 药理学、生物化学和分子遗传学。公务员事务局现由19名成员和6名成员组成 来自弗吉尼亚大学(UVA)七个不同系的准成员。通过包括 化学系，该计划提供独特的跨校园机会，带来 与癌症有关的化学反应。自去年以来，公务员事务局领导层已经招募了7名这样的人到弗吉尼亚大学 更新。该方案的外部资金总额超过1100万美元，其中包括170多万美元 来自国家癌症研究所(NCI)的资金和来自其他国家卫生机构的880多万美元 (NIH)实体。该计划的成员严重依赖癌症中心支持的基础设施，特别是 生物分子分析设备和核磁共振仪器。试点基金和研究务虚会 为UVA癌症中心成员之间的富有成效的合作提供了框架。众多人 公务员事务局成员的活跃和互动导致了287次宣传，其中29%是跨计划的 公共出版物和15%的出版物是上次续订以来的方案内出版物。

Detailed understanding of molecular function in biological systems requires information about the three dimensional structures of macromolecules. The wealth of information available from studies in structural biology provides novel and powerful insights into function. Chemical biology, the modulation of protein function by small molecules, provides both tool compounds to explore biological function as well as leads for development of therapeufic agents. The merging of the structural and chemical biology faculfies brings together two groups that speak the same language, the language of molecular structure, making the merger a natural grouping. The Chemical and Structural Biology Program (CSB) defines its overarching goal as the facilitation of this dialogue to accelerate understanding and treatment of cancer. CSB focuses this goal around four thematic elements; (1) Structural and chemical biology targeting transcription factors. (2) Structural and chemical biology targeting signaling molecules, (3) Advancing structural biology technologies, (4) Chemical biology for imaging, detection, and diagnosis. John H. Bushweller, PhD, Professor of Molecular Physiology and Biological Physics, leads the Program with Kevin R. Lynch, Professor of Pharmacology and of Biochemistry and Molecular Genetics. CSB currenfiy comprises 19 Members and 6 Associate Members from seven different departments at the University of Virginia (UVA). By including the Chemistry Department, the Program provides unique, cross-campus opportunities to bring the power of chemistry to bear on cancer. CSB leadership has recruited seven of these individuals to UVA since the last renewal. Total extramural funding for the Program exceeds $11 million, including more than $1.7 million from the National Cancer Insfitute (NCI) and more than $8.8 million from other National Insfitutes of Health (NIH) entities. The Program Members rely heavily on Cancer Center-supported infrastructure, particulariy the Biomolecular Analysis Facility and NMR instrumentation. Pilot Funds and research retreats have provided the framework for productive collaborations among UVA Cancer Center members. The many activifies and interactions of CSB Members have led to 287 publicafions, of which 29% were interprogrammatic publicafions and 15% were intra-programmatic publications since the last renewal.