Institutional Training Grant in Pediatric Infectious Disease

描述（由申请人提供）：对培训儿科传染病医师科学家的需求从未如此之大。尽管在疫苗和抗菌剂方面取得了进展，但新的传染病经常出现、重新出现或对现有疗法产生耐药性。这些新的传染性挑战需要密集和多样化的培训，比如杜克大学医学中心提供的培训。最佳的培训环境需要在儿科传染病和现代科学方法方面知识渊博的精明临床医生，他们可以开发新的方法来理解和治疗儿童感染。杜克大学儿科传染病培训项目拥有良好的环境和资源，可以提供临床医学方面的特殊培训，以及基础科学、临床、卫生服务或全球健康调查方面的最新研究培训。参与的教员分为四个重点研究领域，选择这些领域是为了给受训人员提供最大的机会，发展处理儿童传染病主要问题所必需的技能。这四个方面包括：1)细菌致病与感染；2)真菌的发病机制与感染；3)全球卫生和艾滋病毒/艾滋病；4)定量科学与临床结果。来自其他临床和基础科学部门的教师有目的的混合有助于促进合作互动，并为学员提供与每个领域的领导者密切合作的机会。经过深思熟虑的导师选择过程是协调的，以确保强大和一致的指导，所有项目的教师导师都是在研究和培训方面取得成功的知名调查员。培训包括每周强制性的结构化核心课程研讨会，12小时的科学写作课程，强制性的研究生课程，以及定期向实验室和研究小组进行口头报告。科学监督委员会每半年向内部咨询委员会提交一份书面报告，随后由外部咨询委员会进行年度审查。学员需要撰写至少两份资助申请，在国家或国际会议上发表摘要，并在至少三份同行评审的出版物上担任主要作者。学员还将受益于一项延长的正式指导计划，该计划将在完成培训计划后持续三年，旨在促进他们过渡到成功的学术生涯。此申请要求支持一名PGY5学员和两名PGY6学员。该培训计划与详细而有力的指导和评估计划相关联，将使受训者能够发展必要的知识和理解，以从事儿科传染病学术研究事业。这项培训经费将使我们能够培养具有创新精神的儿科医师和科学家，使他们做好充分准备，从事独立的学术事业，研究儿科传染病的关键问题。学员将成为传染病领域的领军人物，成为未来儿科医学家的重要导师。

DESCRIPTION (provided by applicant): The need for training pediatric infectious disease physician scientists has never been greater. Despite advances in vaccines and antimicrobials, new infectious diseases frequently emerge, re-emerge, or develop resistance to available therapies. These new infectious challenges require intense and diverse training such as that provided at Duke University Medical Center. The optimal training milieu requires astute clinicians knowledgeable in pediatric infectious diseases and skilled in modern scientific methods who can develop novel approaches to the understanding and treatment of childhood infections. The Duke University Pediatric Infectious Diseases training program has the environment and resources to provide exceptional training in clinical medicine and state of the art research training in basic science, clinical, health services, or global health investigation. The participating faculty is divided into four areas of research emphasis, areas selected to provide trainees with maximal opportunity to develop skills essential for addressing the major issues in childhood infectious diseases. The four areas include: 1) Bacterial Pathogenesis and Infection; 2) Fungal Pathogenesis and Infection; 3) Global Health and HIV/AIDS; and 4) Quantitative Sciences and Clinical Outcomes. A purposeful mixture of faculty from other clinical and basic science departments serves to foster collaborative interactions and to provide trainees with the opportunity to work closely with leaders in each field. A deliberate process for mentor selection is coordinated to ensure strong and consistent mentoring, and all program faculty mentors are established investigators with proven success in research and training. Training includes weekly mandatory seminars in a structured Core Curriculum, a 12-hour scientific writing course, mandatory graduate coursework, and regular oral presentations to laboratory and research groups. A Scientific Oversight Committee provides a written report to the Internal Advisory Committee semi-annually, followed by an annual review by the External Advisory Committee. Trainees are required to write at least two grant applications, present an abstract at a national or international meeting, and be a primary author on at least three peer-reviewed publications. Trainees also benefit from an extended formal mentorship program that will continue for three years after completing the training program, designed to facilitate transition into a successful academic career. This application requests support for one PGY5 trainee and two PGY6 trainees. This training program, linked with a detailed and robust mentoring and evaluation program, will allow trainees to develop the knowledge and understanding necessary to pursue independent research careers in academic pediatric infectious disease. This training grant will allow us to develop innovative pediatric physician-scientists fully prepared to pursue independent academic careers investigating critical issues in pediatric infectious diseases. The trainees will become the leaders in the field of infectious diseases and become key mentors to future pediatric physician-scientists.