Predoctoral Training in Pharmacological Sciences

描述(由申请人提供)：这项资助提案重新提交寻求支持威尔康奈尔医学研究生院(WCGSMC)非常成功的博士前药理学培训计划，该计划已经完成了NIGMS最初的五年资助期。WCGSMS的药理学培训计划是跨部门和跨机构的，由来自威尔·康奈尔医学院和斯隆-凯特琳研究所的杰出研究人员组成。这些机构提供了非常丰富的研究环境，包括最先进的仪器和核心设施，为药理学项目分配了大量的空间，并继续致力于招聘最聪明和最好的新教师。这些机构中的每一家都为其生物医学研究项目的发展做出了重大贡献，在接下来的五年里花费了13亿美元。27名参与教职员工是一群具有凝聚力的世界级研究人员，他们拥有扎实的记录，可以培养未来的科学领袖和学者。在过去的五年中，我们的教员培训人员队伍扩大了，增加了六个新的培训实验室，其中包括几个初级教员实验室。一位少校 该计划的重点是与学员分享发现的兴奋，培养学生的批判性推理能力，并向学生灌输成为有效的生物医学研究人员所需的所有技能。在过去的10年里，我们的TG教师共同为191名卓有成效的博士前实习生的发展做出了贡献。我们的教师导师高度合作，研究兴趣广泛-他们为学员提供翻译生物医学、心血管药理学、神经药理学、癌症生物学、细胞信号、新陈代谢、化学生物学、合成化学、计算生物学和结构生物学等领域的广泛研究机会。该项目通常每年招收10-12名优秀博士前学生，其中8-10名符合培训条件。例如，我们最近进入的班级由11名学生组成，其中10名符合培训条件--这个班级的平均GPA为3.48，GRE平均成绩为H 80%。被录取的学生通常获得美国顶尖大学的本科学位，并拥有丰富的本科生研究经验。目前，我们有69名博士前学生正在接受培训，这还不包括另外一批医学博士/博士。在这组69名仅限博士学位的博士前实习生中，57人符合培训条件，5人来自代表性不足的少数民族(URM)或身体残疾。在我们最初五年的资助中，该项目将在10名不同教员的实验室支持14名优秀的博士前学生的培训；14名受训人员中有2/14来自URM或肢体残疾团体。本申请旨在为药理学专业有效的博士前培训项目的持续发展提供支持。

DESCRIPTION (provided by applicant): This grant proposal resubmission seeks support for a highly successful predoctoral Pharmacology Training Program at the Weill Cornell Graduate School of Medical Sciences (WCGSMC) that has completed an initial five-year period of funding by NIGMS. The Training Program in Pharmacological Sciences at WCGSMS is inter-departmental and inter-institutional, comprising a faculty of distinguished investigators assembled from the Weill Cornell Medical College and Sloan-Kettering Institute. These institutions provide an exceedingly rich research environment, including state-of-the-art instrumentation and core facilities, a generous space allocation to the Pharmacology Program and a continuing commitment to recruiting the brightest and best new faculty. Each of these institutions has made a major contribution to growing their biomedical research programs, at a cost of > $1.3 billion over the next five years. The twenty-seven participating faculty are a cohesive group of world-class investigators with solid records for training future scientific leaders and scholars. During the past five years, our group of faculty trainers has been expanded with the addition of six new training labs, including several junior faculty labs. A major emphasis of the Program is to share the excitement of discovery with trainees, cultivate the student's capacity for critical reasoning, and instill in students all necessary skills to become effective biomedical researchers. Together, our TG faculty has contributed to the development of 191 unusually productive predoctoral trainees during the past 10 years. Our faculty mentors are highly-collaborative and have diverse research interests - they provide trainees with broad research opportunities in the areas of translational biomedicine, cardiovascular pharmacology, neuropharmacology, cancer biology, cell signaling, metabolism, chemical biology, synthetic chemistry, computational biology and structural biology. The Program typically enrolls 10-12 outstanding predoctoral students annually, including 8- 10 that training-eligible. For example, our recent entering class was comprised of 11 students, of which 10 are training-eligible - this class had a mean GPA of 3.48 and mean GRE scores of H 80 percentile. Recruited students typically receive undergraduate degrees from top universities in the USA and have had significant undergraduate research experiences. Currently, we have 69 predoctoral students in training, not counting an additional group of MD/PhDs. Among this group of 69 PhD-only predoctoral trainees, 57 are training eligible and 5 are from underrepresented minorities (URM) or physically-disabled. During our initial five years of funding, this TG will have supported the training of 14 outstanding predoctoral students in labs of 10 different faculty members; 2/14 trainees were from URM or physically disabled groups. This application seeks support for the continued growth of an effective predoctoral Training Program in the Pharmacological Sciences.