Data Management, Biostatistics and Bioinformatics Core

数据管理、生物统计学和生物信息学戈尔（核心D）是宾夕法尼亚大学医学院（Penn）Morris K. Udall帕金森病卓越研究中心（Udall Center）核心D在这个竞争性的更新申请中的目标是继续资助国家神经疾病和中风研究所（NINDS）的宾夕法尼亚大学Udall中心，以支持宾夕法尼亚大学Udall中心研究人员的数据管理，统计，生物信息学，数据库和相关计算需求。核心D提供的服务包括：（a）支持数据表格/调查表的设计和开发、数据库开发和管理、数据输入、数据库审计跟踪、数据库安全、数据库备份和严格的数据质量控制程序，（B）为所有Penn Udall中心活动提供计算和编程支持，包括实施和整合数据管理和研究所需的硬件和软件升级，中心中心计算机系统的常规和存档场外备份，（c）从研究开始到发表的所有研究方面的生物统计支持，包括研究设计的开发、样本量和把握度计算、随机化方案以及中心数据分析，（d）大型复杂数据集的生物信息学支持，（e）维护和管理Penn Udall网站，（f）促进有效的工作关系，包括Penn Udall中心和NIH指定的PD数据组织中心之间的数据共享。因此，核心D发挥了重要和显著的作用，是至关重要的研究进展和研究在宾夕法尼亚大学尤德尔中心的行为，它将促进宾夕法尼亚大学尤德尔中心和其他尤德尔中心之间的协作互动。

The Data Management, Biostatistics and Bioinformatics Gore (Core D) is an integral part of the University of Pennsylvania School of Medicine (Penn) Morris K. Udall Parkinson's Disease Research Center of Excellence (Udall Center). The goal of Core D in this competing renewal application for continued funding of the Penn Udall Center by the National Institute of Neurological Disorders and Stroke (NINDS) is to support the data management, statistical, bioinformatics, database, and related computational needs of Penn Udall Center investigators. The services provided by Core D include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn Udall Center activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Center, (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, randomization schemes, and performing analyses of the Center data, (d) bioinformatics support for large complex data set, (e) maintaining and curating the Penn Udall website, (f) promoting an effective working relationship including data sharing between the Penn Udall Center and the PD data organizing center designated by NIH. Thus, Core D plays an important and significant role that is critical to the progress of research and the conduct of studies in the Penn Udall Center, and it will foster collaborative interactions between the Penn Udall Center and other Udall Centers.