Interactions between integrative genomic islands and plasmids; role in the spread and loss of antibiotic resistance and pathogenicity determinants

在特定位置整合到细菌染色体上的可移动元件为其细菌宿主贡献了致病性和抗生素耐药性决定因素，但只有少数能够将自己转移到新的宿主中。有些质粒和某些元素可以帮助某些其他的。在这个项目中，将使用遗传学方法来研究质粒和整合元件如何帮助彼此进入新的细菌，或者如何相互竞争以留在同一细胞中。

Mobile elements that integrate into bacterial chromosomes at a specific site contribute pathogenicity and antibiotic resistance determinants to their bacterial host but only a few are able to move themselves into new hosts. Some plasmids and some elements can help certain others. In this project, genetic approaches will be used to investigate how plasmids and integrative elements help one another move into a new bacterium or compete with one another to stay in the same cell.