2014 Sensory Transduction in Microorganisms Gordon Research Conference & Gordon R

描述(由申请者提供)：将在加利福尼亚州文图拉举行的2014年戈登微生物感觉转导研究会议将探讨在理解微生物信号转导系统方面的最新进展。重点将放在细菌受体及其与细胞内网络的相互作用上，涉及磷酸盐传递、双组分系统以及通过环核苷酸、反应性代谢物和群体感应信号传递小分子信号。主题将包括感官输入的基因调节以及运动装置的组装、作用和调节，如细菌鞭毛和菌毛。趋化作用、能量监测、社区行为、群体感应和生物膜形成的机制将是中心主题，特别是在发病机制方面。这些领域将通过分子遗传学、细胞生物学、生物化学和化学生物学以及结构、成像和生物物理方法的尖端应用来解决。来自高分辨率实验的数据将与探测复杂大分子组件的行为和了解信号电路的计算工作配对。将探索新出现的方向，如细胞壁在感应和响应信号中的作用，以及生物技术的原核信号工程。被邀请的演讲者将包括成熟的和早期的调查人员。此外，海报主持人还将争夺简短的热门话题演讲。与会者将享受会议开放和合议的气氛，这为参与科学讨论和促进跨学科合作提供了宝贵的机会。第一次，戈登研究研讨会(GRS)将在GRC之前为博士后和研究生举办。GRS为初级科学家提供了一个支持性的环境，让他们展示自己的工作并接受资深导师的建议。GRS的主题将与GRC的主题平行。STIM社区长期以来一直支持初级科学家，我们认为GRS的建立是继续这项任务的绝佳机会。因此，GRS将帮助我们培养早期调查人员的发展，并促进我们社区的多样性。GRS将减少初级科学家在会议上经常遇到的障碍，并给他们成为正式参与者的信心和技能。由于大量有才华的新研究人员的涌入，原核生物信号转导领域正在经历一场复兴，他们应用先进的计算工具、单分子或细胞成像和高通量基因筛查来提供以前无法获得的答案。整合良好的STIM GRC/GRS将指导那些应用这种方法的人解决我们领域面临的最重要的问题，并将鼓励博士后和学生将他们来之不易的培训应用于最令人兴奋的原核信号新领域。

DESCRIPTION (provided by applicant): The 2014 Gordon Research Conference on Sensory Transduction in Microorganisms to be held in Ventura CA will explore recent advances in understanding microbial systems of signal transduction. Focus will be placed on bacterial receptors and their interactions with intracellular networks that involve phosphorelays, two-component systems, and small molecule signaling by cyclic nucleotides, reactive metabolites and quorum sensing signals. Topics will include gene regulation by sensory input and the assembly, action and regulation of motility apparatuses, such as bacterial flagella and pili. Mechanisms underlying chemotaxis, energy monitoring, community behavior, quorum sensing and biofilm formation will be central themes, especially with respect to pathogenesis. These areas will be addressed through cutting-edge applications of molecular genetics, cell biology, biochemistry, and chemical biology as well as structural, imaging and biophysical approaches. Data from high-resolution experiments will be paired with computational efforts to probe the behavior of complex macromolecular assemblies and understand signaling circuitry. Emerging directions such as the role of the cell wall in sensing and responding to signals and the engineering of prokaryotic signaling for biotechnology will be explored. Invited speakers will include both established and early-stage investigators. In addition, poster presenters will compete for short hot-topic talks. Participants will enjoy the Conference's open and collegial atmosphere that provides valuable opportunities to engage in scientific discussion and foster interdisciplinary collaboration. For the first time, a Gordon Research Seminar (GRS) for postdocs and graduate students will precede the GRC. The GRS provides a supportive environment for junior scientists to present their work and receive advise by senior mentors. Topics at the GRS will parallel those of the GRC. The STIM community has long supported junior scientists, and we see the establishment of the GRS as an excellent opportunity to continue on this mission. Thus, the GRS will help us nurture the development of early stage investigators and promote diversity within our community. The GRS will reduce barriers junior scientists often encounter at meetings and give them the confidence and skills to be full-fledged participants. The field of prokaryotic signal transduction has been undergoing a revitalization due to an influx of talented new researchers who apply advanced tools of computation, single molecule or cell imaging and high throughput genetic screening to provide answers previously unattainable. The well-integrated STIM GRC/GRS will direct those applying such methods to the most important questions confronting our field and will encourage postdocs and students to apply their hard-won training to the most exciting new areas of prokaryotic signaling.