Training Program in Investigative Gastroenterology

描述(由申请人提供)：本继续胃肠病学研究培训计划的目标是为学术胃肠病学领域的独立研究人员培养医学博士、博士或医学/博士博士后研究员。经验丰富的多元化教师将有机会在五个广泛领域之一的指导下学习细胞和分子生物学的当代方法或临床研究：A)损伤、纤维化信号和基因调控；B)癌症生物学和遗传学；C)免疫学和病毒学；D)新陈代谢、发育和干细胞的分子基础；或E)以患者为导向的肝胆和胃肠道疾病临床研究。培训将提供 为未来研究胃肠病学的成功奠定坚实的基础。为此，已从胃肠病、肝病、肾脏病、血液病/肿瘤科、传染病、临床免疫学和内分泌科以及其他两个系和六个研究所和中心招聘了专家教员。学员将从以下四个来源之一进入该计划：1)在西奈山医学院完成至少18个月的临床胃肠病学奖学金；2)在西奈山医学院完成临床胃肠病学奖学金和一年的临床肝病；3)在获得生命科学博士学位后，或4)在完成特殊候选人的医学住院医师资格之后。实习生候选人将至少花两年时间进行实验室或患者研究方面的培训。每年这笔赠款将 继续支持3名四至六年级的受训人员。到目前为止，助学金学员强大的生产力和学术职业选择加强了这个已有10年历史的项目的成功。学员将至少有90%的时间在实验室或临床环境中，在教师导师(S)的指导下进行个性化研究项目。此外，所有受训人员每周参加实验室或临床小组会议，参加相关的部门、部门和机构以研究为导向的会议，并参加专门设计的实验室或临床研究方法课程。这项强调翻译研究的综合建议将培养未来研究胃肠病学的学术领袖。这种培训对于推动对数千万受胃肠道和肝胆疾病影响的美国人的护理至关重要，包括通过严格的培训对受影响患者的临床管理采取新的方法。

DESCRIPTION (provided by applicant): The goal of this continuation Gastroenterology Research Training Program proposal is to prepare M.D., Ph.D., or M.D./Ph.D. postdoctoral fellows for careers as independent investigators in academic Gastroenterology. A diverse, experienced faculty will provide the opportunity to learn contemporary methods of cellular and molecular biology or clinical research by mentorship in one of five broad areas: A) Injury, Fibrosis Signaling & Gene Regulation; B) Cancer Biology & Genetics; C) Immunology and Virology; D) Molecular Basis of Metabolism, Development & Stem cells; or E) Patient-oriented Clinical Investigation in Hepatobililary and Gastrointestinal Diseases. The training will provide a solid foundation for future success in investigative Gastroenterology. To do so, expert faculty have been recruited from the Divisions of Gastroenterology, Liver Diseases, Nephrology, Hematology/Oncology, Infectious Diseases, Clinical Immunology and Endocrinology, and from two other Departments and six Research Institutes and Centers. Trainees will enter the program from one of four sources: 1) Following completion of least 18 months of clinical Gastroenterology fellowship at the Mount Sinai School of Medicine; 2) Following completion of a clinical Gastroenterology fellowship plus a year of clinical Hepatology at the Mount Sinai School of Medicine; 3) After the awarding of a Ph.D. degree in life sciences, or 4) Following completion of a Medicine Residency for exceptional candidates. Trainee candidates will devote a minimum of two years to training in either laboratory- or patient-based research. Each year this grant will continue support 3 trainees at the PGY 4 - PGY 6 level. The strong productivity and academic career choices of the grant's trainees to date reinforce the success of this 10 yr-old program. At least 90% of trainees' time will be devoted to working in the laboratory or clinical setting on an individualized research project under the guidance of faculty mentor(s). In addition, all trainees participate in weekly laboratory or clinical group meetings, attend relevant divisional, departmental and institutional research-oriented conferences, and enroll in specifically designed coursework in laboratory or clinical investigative methods. This integrated proposal emphasizing translational research will train future academic leaders in investigative gastroenterology. Such training will be essential to enable advances in the care of tens of million Americans affected by gastrointestinal and hepatobiliary diseases, including new approaches to the clinical management of affected patients through rigorous training.