FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE

描述(由申请人提供)：FlyBase是重要的生物医学模型果蝇及其相关物种的核心基因组/遗传模式生物数据库(MOD)。果蝇是首屈一指的动物研究系统之一，可以非常经济高效地用于帮助了解人类遗传疾病的病因，并且是最接近的实验模型，可以提供对人类疾病的昆虫媒介(如携带疟疾等重大传染病的蚊子)生物学的洞察。西尼罗河病毒。目标有两个：(1)为果蝇的遗传/基因组数据和实验试剂提供集中的资源，以便使果蝇的研究尽可能快地发展；(2)向更广泛的生物医学研究社区提供这些结果，以促进他们自己的研究。FlyBase通过FlyBase策展人的注释、直接用户提交和自动文本挖掘，从主要科学文献以及大规模基因组分析和功能基因组学社区资源项目中获取数据。FlyBase和协作信息学资源广泛共享数据，从而利用每个小组的输出。根据一系列本体组织系统，将这些异质数据组织成一致的数据集，并集成到一个中央数据库中。每两个月一次，这些数据从中央FlyBase数据库中提取，并通过可免费访问的FlyBase网站提供给整个科学界，该网站每月被访问数百万次。除了向研究社区提供以便于查询和浏览的方式收集FlyBase捕获的数据之外，FlyBase还维护着数百万个指向其他生物医学网站的链接，这些网站提供其他相关信息。在拟议的5年资助期内，FlyBase希望为增强国防部的互操作性做出贡献，并与广泛的信息学资源和期刊出版商合作，为生物医学研究社区提供尽可能丰富的一套数据和数据挖掘工具。 相关性：FlyBase提供关键的数据和信息基础设施，以加快果蝇研究的步伐，并让更广泛的生物医学科学界利用这些发现来促进他们自己的研究。果蝇现在是一个被广泛接受的人类疾病研究的实验模型，也是研究携带人类疾病的昆虫媒介的最接近的遗传/基因组实验模型系统。

DESCRIPTION (provided by applicant): FlyBase is the core genomic / genetic Model Organism Database (MOD) for the important biomedical model, Drosophila melanogaster and related species of flies. Drosophila is one of the premiere animal research systems and can be used very cost-effectively to help understand the etiology of human genetic diseases and is the closest experimental model that care provide insights into the biology of insect vectors of human disease (such as mosquitos that carry major infectious diseases such as malaria. West Nile Virus. The goals are twofold: (1) to provide a centralized resource for Drosophila genetic/genomic data and experimental reagents in order to enable Drosophila research to advance as rapidly as possible and (2) to provide these results to the broader biomedical research community to further their own research. FlyBase captures data from the primary scientific literature and from large-scale genome analysis and functional genomics community resource projects through annotation by FlyBase curators, direct user submissions and automated text-mining. FlyBase and collaborating informatics resources extensively share data thereby leveraging the output of each group. These heterogeneous data are organized into coherent datasets and integrated in a central database according to a series of ontology organizing systems. On a bi-monthly basis, these data are extracted from the central FlyBase database and served to the entire scientific community through a freely accessible FlyBase website, which is accessed millions of times each month. In addition to providing the research community to ttie corpus of FlyBase-captured data in ways that can be readily interrogated and browsed, FlyBase also maintains millions of links to other biomedical websites providing other relevant information. Over the proposed 5-year grant period, FlyBase expects to contribute to the enhancement of MOD interoperability and to work with a broad range of informatics resources and journal publishers to provide as rich a set of data and data-mining tools as possible to the biomedical research community. RELEVANCE: FlyBase provides crucial data and informatic infrastructure to accelerate the pace of Drosophila research and for the broader biomedical sciences community to leverage these discoveries to further their own research. Drosophila is now a well-accepted experimental model for human disease research and is the closest genetic / genomic experimental model system for research on the insect vectors that carry human diseases.