Core B: Clinical

临床核心-核心B：摘要 临床核心（核心B）在BIOCARD研究中发挥关键作用。临床中心负责：（1） 重新入组BIOCARD受试者，（2）安排受试者进行所有访视和所有研究程序 （包括临床/认知评估、腰椎穿刺以收集脑脊液、磁共振成像） 共振成像（MRI）扫描和使用匹兹堡化合物B的正电子发射断层扫描 (PiB/PET扫描），（3）完成年度临床和认知评估，（4）获得生前检查结果， 尸检批准，（5）实施受试者保留活动，（6）分析临床和认知数据 关于研究参与者，（7）与其他核心合作，检查以下组合： 生物标志物，预测进展，并检查生物标志物变化的顺序和模式， 临床前AD，以及（8）通过BIOCARD与该领域的研究者共享临床和认知数据 网站，使用批准的BIOCARD研究数据共享程序。

CLINICAL CORE - CORE B: ABSTRACT The Clinical Core (Core B) plays a pivotal role in the BIOCARD Study. The Clinical Core is responsible for: (1) the re-enrollment of BIOCARD subjects, (2) scheduling subjects for all visits and all study procedures (including clinical/cognitive assessments, lumbar punctures for collection of cerebrospinal fluid, magnetic resonance imaging (MRI) scans, and positron emission tomography scans using Pittsburgh compound B (PiB/PET scans), (3) completion of annual clinical and cognitive assessments, (4) acquisition of ante-mortem autopsy approval, (5) implementation of subject retention activities, (6) analyses of clinical and cognitive data concerning the study participants, (7) working collaboratively with the other Cores to examine combinations of biomarkers that are predictive of progression and to examine the order and pattern of biomarker change during preclinical AD, and (8) sharing of clinical and cognitive data with investigators in the field via the BIOCARD website, using the approved BIOCARD Study data sharing procedures.