toxic and potential of vanadyl sulfate and sodium metavanadate in laboratory animals for the National Toxicology Program (NTP)

该项目的目的是评估五价（偏氰酸钠）和四价（硫酸钒基）钒化合物在饮用水中暴露后的毒性。两种化合物为期两周的研究都处于临床阶段。人类很可能同样会在饮用水中接触到这些化合物。由于这些化合物的毒性数据很少，这些短期研究为设计更明确的生殖/发育和慢性毒性/致癌性研究提供了有价值的数据。此外，为期两周的研究设计相似，允许比较五价和四价钒的毒性。

The goal of this project is to evaluate the toxicity of pentavalent (sodium metavanadate) and tetravalent (vanadyl sulfate) vanadium compounds, following exposure in drinking water. Two-week studies of both compounds are in the in life phase. Humans are likely to be similarly exposed to these compounds in drinking water. As there are little available toxicity data on these compounds, these short-term studies provide valuable data to design more definitive reproductive/developmental and chronic toxicity/carcinogenicity studies. In addition, the 2-week studies were designed similarly to allow comparisons of the toxicity between pentavalent and tetravalent vanadium. Keywords: toxicity, drinking water, vanadium, pentavalent, tetravalent, vanadyl sulfate, sodium metavanadate.