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中文摘要
翻译
发展基金继续在癌症中心的全球重组中发挥关键作用,该重组是在CCSG上一个预算期间发起的。在全面、透明和包容的战略规划过程的支持下,癌症中心在行政基础设施、科学和教育目标的细化、项目主题的扩展和共享资源的全球重新调整方面发生了重大变化。此次重组的一个关键方面是有重点的、有主题的教师招聘工作,在上一个预算期间,癌症中心在三个科学项目中分别招聘了9名新的学术级别的癌症中心成员。作为灵活、包容和目标导向的决策过程的一部分,CCSG发展基金在实现2012年癌症中心战略计划的长期指令方面发挥了重要作用,为新教师招聘做出了贡献,促进了跨项目和合作试点项目的开展,支持了新的发展转化研究管理核心的启动。扩大临床注释原发肿瘤样本的收集,用于分子验证研究、预后生物标志物评估和新癌症靶点的鉴定。在此背景下,CCSG发展基金在上一个预算期内为癌症中心的急剧上升做出了实实在在的贡献,这体现在癌症重点的显著增加、NCI和癌症相关资金的增长、项目间和项目内合作出版物的扩大,以及在基础、转化和以患者为导向的癌症研究的连续体上启动了一系列科学倡议。在这些经过验证的原则的基础上,CCSG发展基金将在下一个预算期内继续支持癌症中心的上升轨迹,支持新的教职员工招聘,并扩大中心范围内的工具,这些工具已经到位,可以在所有三个科学项目中进行转化和以患者为导向的癌症研究。
英文摘要
: Developmental Funds have continued to play a key role in the global reorganization of the Cancer Center that was initiated during the last CCSG budget period. Supported by a thorough, transparent and inclusive strategic planning process, the Cancer Center has undergone major changes in its administrative infrastructure, refinement of scientific and educational objectives, expansion of programmatic themes and global realignment of Shared Resources. A pivotal aspect of this reorganization was a focused and thematic faculty recruitment effort that led to the hiring of nine new Cancer Center members at all academic ranks and appointed across the three scientific Programs during the last budget period. Judiciously deployed as part of a flexible, inclusive and goal-oriented decision-making process, CCSG Developmental Funds have been instrumental to enable the long-range directives ofthe 2012 Cancer Center Strategic Plan, contributing to new faculty recruitment, facilitating inter-programmatic and collaborative pilot projects, supporting the launch of a new developmental Translational Research Management core, and expanding the collection of clinically annotated primary tumor samples for molecular validation studies, prognostic biomarker assessment and identification of new cancer targets. In this context, CCSG Developmental Funds have tangibly contributed to the sharp upward trajectory of the Cancer Center of the last budget period, reflected in significantly increased cancer focus, growth in NCI and cancer-related funding, expansion of inter- and intraprogrammatic collaborative publications, and launch of a portfolio of scientific initiatives along the continuum of basic, translational and patient-oriented cancer research. Building on these validated principles, CCSG Developmental Funds will continue to support the upward trajectory of the Cancer Center over the next budget period, supporting new faculty recruitment and expanding the Center-wide tools that have been put in place to enable translational and patient-oriented cancer research across all three scientific Programs.
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Augmenting T-cell immunotherapy outcomes in blood and solid tumor microenvironment in ART-suppressed HIV infection (immune/microenvironment)
  • 批准号:
    10620011
  • 项目类别:
  • 资助金额:
    $12.42万
  • 财政年份:
    2022
  • 负责人:
    Dario C Altieri
  • 依托单位:
A First-in-Human Phase I Clinical Trial of Mitochondrial-Targeted Hsp90 Inhibitor, Gamitrinib
  • 批准号:
    10472429
  • 项目类别:
  • 资助金额:
    $31.63万
  • 财政年份:
    2021
  • 负责人:
    Dario C Altieri
  • 依托单位:
A First-in-Human Phase I Clinical Trial of Mitochondrial-Targeted Hsp90 Inhibitor, Gamitrinib
  • 批准号:
    9668658
  • 项目类别:
  • 资助金额:
    $41.03万
  • 财政年份:
    2021
  • 负责人:
    Dario C Altieri
  • 依托单位:
Tumor Plasticity
  • 批准号:
    10474434
  • 项目类别:
  • 资助金额:
    $111.72万
  • 财政年份:
    2017
  • 负责人:
    Dario C Altieri
  • 依托单位:
海外基金