Upgrade of 800 MHz Spectrometer

申请资金将一台已有十多年历史的800兆赫核磁共振波谱仪升级为布鲁克光谱仪 Biospin Avance III HD核磁共振控制台和相关的BMPC-II和冷冻平台单元，现在是 过时且越来越不可靠。请求的设备将安装在现有的Bruker上 SpectrSpin主动屏蔽了18.8T磁体，并将利用现有的z梯度TCI CryoProbe。 所要求的800兆赫核磁共振波谱仪的升级对于超越目的是必不可少的 纽约结构生物学中心(NYSBC)是由纽约九家研究机构组成的联盟 纽约州，以支持NIH资助的针对主要和次要用户的研究的特定目标 分光计。在800 MHz仪器上进行的研究范围从基础研究到 研究生物分子的结构/功能，阐明发病机制，发现 新型先导化合物在医药领域的应用。请求的每个组件 设备提供了显著的性能改进，从整体上讲将显著 提升800兆赫核磁共振波谱仪进行这项研究的能力。

Funding is requested to upgrade a more than ten-year-old 800 MHz NMR spectrometer with a Bruker Biospin AVANCE III HD NMR Console and associated BMPC-II and CryoPlatform units that are now obsolete and increasingly unreliable. The requested equipment will be installed on an existing Bruker Spectrospin actively shielded 18.8 T magnet and will utilize the existing z-gradient TCI CryoProbe. The requested upgrades of the 800 MHz NMR spectrometer are essential to the over-riding purpose of the New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State, to support the particular aims of the NIH-funded research of the major and minor users of the spectrometer. Research conducted on the 800 MHz instrument ranges from fundamental studies of structure/function of biomolecules, to elucidation of mechanisms of pathogenesis, to discovery of novel lead compounds to pharmaceutical applications. Each of the components of the requested equipment provides significant improvements in performance that in their entirety will dramatically enhance the capacity of the 800 MHz NMR spectrometer to conduct this research.