Training Program in Stem Cell and Cancer Biology

描述（由申请人提供）：干细胞的研究打破了严格的细胞谱系限制的概念，为再生提供了有希望的方法，并为癌症的起因和治疗提供了新的视角。纽约大学医学院干细胞和癌症生物学（SCCB）培训基金的目的是在这一快速发展的研究领域提供培训。我们的明确目标是使学员能够深刻理解为这一新的、可能具有变革性的研究领域提供基础的方法、原则和问题。具体来说，SCCB项目旨在培养正常和癌症干细胞生物学领域的学生和博士后，以阐明当干细胞/祖细胞以不适当的方式激活时促进恶性转化的机制和途径。该项目的长期目标是培养一批新的研究人员骨干，他们在干细胞和癌症生物学方面具有广泛的跨学科知识，可能会更好地了解癌症的原因，最终可能会导致新的靶向治疗肿瘤的发展。SCCB项目的重点是使受训者获得作为癌症干细胞生物学领域独立科学家的成功职业所需的技能，使他们能够培养独立和严格的关键技能。这16位SCCB导师都是高生产力的科学家，他们中的大多数都有NCI和其他癌症相关的资助。10年来，共培养学生72人，博士后96人。SCCB项目将在一个高度互动的科学环境中提供智力要求高的博士前和博士后培训，在一个鼓励多样性的广泛培训环境中提供严格的课程、教程和研讨会。多层指导计划将允许监测研究进展。学员还将获得批判性地评估科学数据和文献的能力，并将发展他们的写作和演讲技巧。对学生的培训将包括干细胞生物学、遗传学和分子肿瘤学的严格课程。所有受训者都将参加干细胞生物学系列研讨会、年度务静会、期刊俱乐部和讨论小组，以及以科学道德行为和职业选择为重点的讲座。从33名符合条件的博士预科生（按2009年招生人数计算）和110名符合条件的博士后学员（按当前博士后学员总数计算）中选出2名博士预科生和4名博士后学员。这些受训者将代表新一代科学家，他们可以为开发治疗恶性疾病的新疗法做出贡献。

DESCRIPTION (provided by applicant): The study of stem cells has shattered the concept of strict cell lineage restriction, has provided promising approaches to regeneration and has given a new perspective on the causes and treatments of cancers. The intent of the Stem Cell and Cancer Biology (SCCB) training grant at New York University School of Medicine is to provide training in this rapidly developing research field. It is our explicit goal to empower trainees with a deep understanding of the methods, principles and questions that provide the base of this new and likely transformative research area. Specifically, the SCCB program aims to train students and postdoctoral fellows in the fields of normal and cancer stem cell biology in order to elucidate mechanisms and pathways that when activated in an inappropriate manner in stem/progenitor cells contribute to malignant transformation. A long- term goal of the program is to train a new cadre of researchers whose broad and interdisciplinary knowledge of stem cell and cancer biology may result in a better understanding of the causes of cancer that may eventually lead to the development of new targeted therapies to treat tumors. The SCCB program focuses on enabling trainees to acquire the skills needed for successful careers as independent scientists in the cancer stem cell biology field by empowering them to develop independent and rigorous critical skills. The 16 SCCB mentors are highly productive scientists most of whom have NCI and other cancer related funding. They have trained a total of 72 students and 96 post-doctoral fellows in the past 10 years. The SCCB program will provide intellectually demanding pre- and postdoctoral training in a highly interactive scientific environment providing rigorous courses, tutorials, and seminars in a broad training environment that encourages diversity. Multi-tiered mentoring plans will allow monitoring of research progress. Trainees will also acquire the ability to critically evaluate scientific data and literature and will develop their writing and presentation skills. Training of students will include rigorous courses in Stem Cell Biology, Genetics and Molecular Oncology. All trainees will participate in the stem cell biology seminar series, an annual retreat, journal clubs and discussion groups as well as lectures focusing on ethical conduct in science and career options. Funds are requested to support 2 pre- and 4 postdoctoral trainees out of a total trainee group of 33 eligible pre- (based on 2009 admissions) and 110 eligible postdoctoral trainees (based on current postdoctoral trainee totals). These trainees will represent a new generation of scientists who can contribute to the development of novel therapies to treat malignant diseases.