Development of a pedigreed baboon genome resource for biomedical research

描述（由申请人提供）：狒狒是许多复杂性状的重要生物医学模型，包括运动能力、骨密度和肥胖。狒狒具有短的世代时间和控制环境的能力，为人类复杂特征的遗传研究提供了天然的补充。然而，狒狒的高分辨率遗传研究受到缺乏基因组资源的阻碍。我们将通过提高狒狒基因组组装的质量，提供狒狒基因组中常见多态性和单倍型的综合图谱，以及构建狒狒的高分辨率遗传图谱来解决这一差距。总之，这些资源将使未来的狒狒精细规模的基因型-表型研究，这反过来可能导致重要的生物医学进步，了解人类疾病的遗传基础。

DESCRIPTION (provided by applicant): Baboons are an important biomedical model for many complex traits, including athlerosclerosis, bone density and obesity. With short generation times and an ability to control the environment, baboons provide a natural complement to human genetic studies of complex traits. However, high-resolution genetic studies in baboons are hampered by a lack of genomic resources. We will address this gap by improving the quality of the baboon genome assembly, providing comprehensive maps of common polymorphisms and haplotypes across the baboon genome, and constructing a high-resolution genetic map for baboons. Together, these resources will enable future fine-scale genotype-phenotype studies in baboons, which in turn may lead to important biomedical advances in understanding the genetic basis of human disease.